Synthesis of cyanooxovanadate and cyanosilylation of ketones

The cyanosilylation was performed by using metavanadate catalysts, and in situ measurements revealed the formation of [VO(2)(CN)(3)](2−) and [VO(4)TMS(2)](−) under reaction conditions. The reaction of [VO(2)(CN)(3)](2−), trimethylsilyl cyanide (TMSCN), and water afforded [VO(4)TMS(2)](−) and CN(−),...

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Detalles Bibliográficos
Autores principales: Kikukawa, Yuji, Kawabata, Hiroko, Hayashi, Yoshihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041443/
https://www.ncbi.nlm.nih.gov/pubmed/35496882
http://dx.doi.org/10.1039/d1ra05879g
Descripción
Sumario:The cyanosilylation was performed by using metavanadate catalysts, and in situ measurements revealed the formation of [VO(2)(CN)(3)](2−) and [VO(4)TMS(2)](−) under reaction conditions. The reaction of [VO(2)(CN)(3)](2−), trimethylsilyl cyanide (TMSCN), and water afforded [VO(4)TMS(2)](−) and CN(−), which reacted with ketones to yield the corresponding cyanohydrin trimethylsilyl ethers over [VO(2)(CN)(3)](2−). Compound [VO(2)(CN)(3)](2−) showed high catalytic performance for cyanosilylation of various carbonyl compounds. In the case of n-hexanal, turnover frequency reached up to 250 s(−1).

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