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How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector
Novel bacteriophages (phages) possessing a broad host range are consistently and routinely reported, yet there is presently no consensus on the definition of “broad host range.” As phages are increasingly being used in the development of methods for the detection and biocontrol of human pathogens, i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041489/ https://www.ncbi.nlm.nih.gov/pubmed/36148040 http://dx.doi.org/10.1089/phage.2020.0036 |
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author | Fong, Karen Wong, Catherine W.Y. Wang, Siyun Delaquis, Pascal |
author_facet | Fong, Karen Wong, Catherine W.Y. Wang, Siyun Delaquis, Pascal |
author_sort | Fong, Karen |
collection | PubMed |
description | Novel bacteriophages (phages) possessing a broad host range are consistently and routinely reported, yet there is presently no consensus on the definition of “broad host range.” As phages are increasingly being used in the development of methods for the detection and biocontrol of human pathogens, it is important to address the limitations associated with the host range. For instance, unanticipated host range breadth may result in the detection of nonpathogenic targets, thereby increasing the false-positive rate. Moreover, a broad host range is generally favored in biocontrol applications despite the risk of undesirable ancillary effects against nontarget species. Here, we discuss the research progress, applications, and implications of broad host range phages with a focus on tailed broad host range phages infecting human pathogens of concern in the Agri-Food sector. |
format | Online Article Text |
id | pubmed-9041489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-90414892022-09-21 How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector Fong, Karen Wong, Catherine W.Y. Wang, Siyun Delaquis, Pascal Phage (New Rochelle) Review Novel bacteriophages (phages) possessing a broad host range are consistently and routinely reported, yet there is presently no consensus on the definition of “broad host range.” As phages are increasingly being used in the development of methods for the detection and biocontrol of human pathogens, it is important to address the limitations associated with the host range. For instance, unanticipated host range breadth may result in the detection of nonpathogenic targets, thereby increasing the false-positive rate. Moreover, a broad host range is generally favored in biocontrol applications despite the risk of undesirable ancillary effects against nontarget species. Here, we discuss the research progress, applications, and implications of broad host range phages with a focus on tailed broad host range phages infecting human pathogens of concern in the Agri-Food sector. Mary Ann Liebert, Inc., publishers 2021-06-01 2021-06-16 /pmc/articles/PMC9041489/ /pubmed/36148040 http://dx.doi.org/10.1089/phage.2020.0036 Text en © Karen Fong et al. 2021; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by-nc/4.0/This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited. |
spellingShingle | Review Fong, Karen Wong, Catherine W.Y. Wang, Siyun Delaquis, Pascal How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector |
title | How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector |
title_full | How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector |
title_fullStr | How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector |
title_full_unstemmed | How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector |
title_short | How Broad Is Enough: The Host Range of Bacteriophages and Its Impact on the Agri-Food Sector |
title_sort | how broad is enough: the host range of bacteriophages and its impact on the agri-food sector |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041489/ https://www.ncbi.nlm.nih.gov/pubmed/36148040 http://dx.doi.org/10.1089/phage.2020.0036 |
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