New total synthesis and structure confirmation of putative (+)-hyacinthacine C(3) and (+)-5-epi-hyacinthacine C(3)

A unique synthesis of polyhydroxylated pyrrolizidine alkaloids, namely (+)-hyacinthacine C(3) and (+)-5-epi-hyacinthacine C(3) is presented. The strategy relies on a 1,3-dipolar cycloaddition of an l-mannose derived nitrone, which owing to its great syn-stereoselectivity builds up the majority of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Dikošová, Lívia, Otočková, Barbora, Malatinský, Tomáš, Doháňošová, Jana, Kopáčová, Mária, Ďurinová, Anna, Smutná, Lucie, Trejtnar, František, Fischer, Róbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041629/
https://www.ncbi.nlm.nih.gov/pubmed/35496868
http://dx.doi.org/10.1039/d1ra06225e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041629/
https://www.ncbi.nlm.nih.gov/pubmed/35496868
http://dx.doi.org/10.1039/d1ra06225e

Ejemplares similares