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New total synthesis and structure confirmation of putative (+)-hyacinthacine C(3) and (+)-5-epi-hyacinthacine C(3)
A unique synthesis of polyhydroxylated pyrrolizidine alkaloids, namely (+)-hyacinthacine C(3) and (+)-5-epi-hyacinthacine C(3) is presented. The strategy relies on a 1,3-dipolar cycloaddition of an l-mannose derived nitrone, which owing to its great syn-stereoselectivity builds up the majority of th...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041629/ https://www.ncbi.nlm.nih.gov/pubmed/35496868 http://dx.doi.org/10.1039/d1ra06225e |