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Transcriptional lockdown during acute proteotoxic stress

Cells experiencing proteotoxic stress downregulate the expression of thousands of active genes and upregulate a few stress-response genes. The strategy of downregulating gene expression has conceptual parallels with general lockdown in the global response to the coronavirus disease 2019 (COVID-19) p...

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Detalles Bibliográficos
Autor principal: Sawarkar, Ritwick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041648/
https://www.ncbi.nlm.nih.gov/pubmed/35487807
http://dx.doi.org/10.1016/j.tibs.2022.03.020