Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-Induced Urothelial Cell Damage

Patients undergoing chemotherapy with cyclophosphamide experience cystitis due to excretion of a toxic metabolite, acrolein. Cystitis, an inflammation of the bladder, is associated with damage to the integrity of the urothelial barrier. The purinergic P2X7 receptor (P2X7R) is increasingly recognized...

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Detalles Bibliográficos
Autores principales: Taidi, Zhinoos, Mansfield, Kylie J., Sana-Ur-Rehman, Hafiz, Moore, Kate H., Liu, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041750/
https://www.ncbi.nlm.nih.gov/pubmed/35492615
http://dx.doi.org/10.3389/fphys.2022.885545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041750/
https://www.ncbi.nlm.nih.gov/pubmed/35492615
http://dx.doi.org/10.3389/fphys.2022.885545

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