Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases

Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR...

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Detalles Bibliográficos
Autores principales: Gjorgjievska, Marija, Mehandziska, Sanja, Stajkovska, Aleksandra, Pecioska-Dokuzovska, Slavica, Dimovska, Anica, Durmish, Idriz, Ismail, Sara, Pavlovska, Teodora, Stojchevska, Antonija, Amedi, Haris, Andonova, Jasna, Nikolovska, Marija, Velickovikj, Sara, Mitrev, Zan, Kungulovski, Ivan, Kungulovski, Goran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041751/
https://www.ncbi.nlm.nih.gov/pubmed/35495156
http://dx.doi.org/10.3389/fgene.2022.892682
Descripción
Sumario:Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host.

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