Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases

Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR...

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Autores principales: Gjorgjievska, Marija, Mehandziska, Sanja, Stajkovska, Aleksandra, Pecioska-Dokuzovska, Slavica, Dimovska, Anica, Durmish, Idriz, Ismail, Sara, Pavlovska, Teodora, Stojchevska, Antonija, Amedi, Haris, Andonova, Jasna, Nikolovska, Marija, Velickovikj, Sara, Mitrev, Zan, Kungulovski, Ivan, Kungulovski, Goran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041751/
https://www.ncbi.nlm.nih.gov/pubmed/35495156
http://dx.doi.org/10.3389/fgene.2022.892682
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author Gjorgjievska, Marija
Mehandziska, Sanja
Stajkovska, Aleksandra
Pecioska-Dokuzovska, Slavica
Dimovska, Anica
Durmish, Idriz
Ismail, Sara
Pavlovska, Teodora
Stojchevska, Antonija
Amedi, Haris
Andonova, Jasna
Nikolovska, Marija
Velickovikj, Sara
Mitrev, Zan
Kungulovski, Ivan
Kungulovski, Goran
author_facet Gjorgjievska, Marija
Mehandziska, Sanja
Stajkovska, Aleksandra
Pecioska-Dokuzovska, Slavica
Dimovska, Anica
Durmish, Idriz
Ismail, Sara
Pavlovska, Teodora
Stojchevska, Antonija
Amedi, Haris
Andonova, Jasna
Nikolovska, Marija
Velickovikj, Sara
Mitrev, Zan
Kungulovski, Ivan
Kungulovski, Goran
author_sort Gjorgjievska, Marija
collection PubMed
description Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host.
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spelling pubmed-90417512022-04-27 Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases Gjorgjievska, Marija Mehandziska, Sanja Stajkovska, Aleksandra Pecioska-Dokuzovska, Slavica Dimovska, Anica Durmish, Idriz Ismail, Sara Pavlovska, Teodora Stojchevska, Antonija Amedi, Haris Andonova, Jasna Nikolovska, Marija Velickovikj, Sara Mitrev, Zan Kungulovski, Ivan Kungulovski, Goran Front Genet Genetics Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host. Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9041751/ /pubmed/35495156 http://dx.doi.org/10.3389/fgene.2022.892682 Text en Copyright © 2022 Gjorgjievska, Mehandziska, Stajkovska, Pecioska-Dokuzovska, Dimovska, Durmish, Ismail, Pavlovska, Stojchevska, Amedi, Andonova, Nikolovska, Velickovikj, Mitrev, Kungulovski and Kungulovski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Gjorgjievska, Marija
Mehandziska, Sanja
Stajkovska, Aleksandra
Pecioska-Dokuzovska, Slavica
Dimovska, Anica
Durmish, Idriz
Ismail, Sara
Pavlovska, Teodora
Stojchevska, Antonija
Amedi, Haris
Andonova, Jasna
Nikolovska, Marija
Velickovikj, Sara
Mitrev, Zan
Kungulovski, Ivan
Kungulovski, Goran
Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
title Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
title_full Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
title_fullStr Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
title_full_unstemmed Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
title_short Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
title_sort case report: omicron ba.2 subvariant of sars-cov-2 outcompetes ba.1 in two co-infection cases
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041751/
https://www.ncbi.nlm.nih.gov/pubmed/35495156
http://dx.doi.org/10.3389/fgene.2022.892682
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