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Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor

Interferons establish an antiviral state through the induction of hundreds of interferon-stimulated genes (ISGs). The mechanisms and viral specificities for most ISGs remain incompletely understood. To enable high-throughput interrogation of ISG antiviral functions in pooled genetic screens while mi...

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Detalles Bibliográficos
Autores principales:	Danziger, Oded, Patel, Roosheel S., DeGrace, Emma J., Rosen, Mikaela R., Rosenberg, Brad R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041830/ https://www.ncbi.nlm.nih.gov/pubmed/35421191 http://dx.doi.org/10.1371/journal.ppat.1010464

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