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Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data

PURPOSE: Growth hormone (GH) treatment has been used to improve growth in short children who were born small for gestational age (SGA). The aim of this study was to investigate the long-term efficacy of GH treatment in these children. METHODS: Data from a multicenter observational clinical trial (Cl...

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Autores principales: Lee, Hae Sang, Kum, Change Dae, Rho, Jung Gi, Hwang, Jin Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041836/
https://www.ncbi.nlm.nih.gov/pubmed/35472208
http://dx.doi.org/10.1371/journal.pone.0266329
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author Lee, Hae Sang
Kum, Change Dae
Rho, Jung Gi
Hwang, Jin Soon
author_facet Lee, Hae Sang
Kum, Change Dae
Rho, Jung Gi
Hwang, Jin Soon
author_sort Lee, Hae Sang
collection PubMed
description PURPOSE: Growth hormone (GH) treatment has been used to improve growth in short children who were born small for gestational age (SGA). The aim of this study was to investigate the long-term efficacy of GH treatment in these children. METHODS: Data from a multicenter observational clinical trial (ClinicalTrials.gov NCT01604395, LG growth study) were analyzed for growth outcome and prediction model in response to GH treatment. One hundred fifty-two children born SGA were included. RESULTS: The mean age of patients born SGA was 7.13 ± 2.59 years. Height standard deviation score (SDS) in patients born SGA increased from -2.55 ± 0.49 before starting treatment to -1.13 ± 0.76 after 3 years of GH treatment. Of the 152 patients with SGA, 48 who remained prepubertal during treatment used model development. The equation describing the predicted height velocity during 1st year of GH treatment is as follows: the predictive height velocity (cm) = 10.95 + [1.12 x Height SDS at initial treatment (score)] + [0.03 x GH dose (ug/kg/day)] + [0.30 x TH SDS at initial treatment (score)] + [0.05 x age (year)] + [0.15 x Weight SDS at initial treatment (score)] ± 1.51 cm. CONCLUSIONS: GH treatment improved growth outcome in short children born SGA. We also developed a prediction model that is potentially useful in determining the optimal growth outcome for each child born SGA. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01604395.
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spelling pubmed-90418362022-04-27 Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data Lee, Hae Sang Kum, Change Dae Rho, Jung Gi Hwang, Jin Soon PLoS One Research Article PURPOSE: Growth hormone (GH) treatment has been used to improve growth in short children who were born small for gestational age (SGA). The aim of this study was to investigate the long-term efficacy of GH treatment in these children. METHODS: Data from a multicenter observational clinical trial (ClinicalTrials.gov NCT01604395, LG growth study) were analyzed for growth outcome and prediction model in response to GH treatment. One hundred fifty-two children born SGA were included. RESULTS: The mean age of patients born SGA was 7.13 ± 2.59 years. Height standard deviation score (SDS) in patients born SGA increased from -2.55 ± 0.49 before starting treatment to -1.13 ± 0.76 after 3 years of GH treatment. Of the 152 patients with SGA, 48 who remained prepubertal during treatment used model development. The equation describing the predicted height velocity during 1st year of GH treatment is as follows: the predictive height velocity (cm) = 10.95 + [1.12 x Height SDS at initial treatment (score)] + [0.03 x GH dose (ug/kg/day)] + [0.30 x TH SDS at initial treatment (score)] + [0.05 x age (year)] + [0.15 x Weight SDS at initial treatment (score)] ± 1.51 cm. CONCLUSIONS: GH treatment improved growth outcome in short children born SGA. We also developed a prediction model that is potentially useful in determining the optimal growth outcome for each child born SGA. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01604395. Public Library of Science 2022-04-26 /pmc/articles/PMC9041836/ /pubmed/35472208 http://dx.doi.org/10.1371/journal.pone.0266329 Text en © 2022 Lee et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Hae Sang
Kum, Change Dae
Rho, Jung Gi
Hwang, Jin Soon
Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data
title Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data
title_full Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data
title_fullStr Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data
title_full_unstemmed Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data
title_short Long-term effectiveness of growth hormone therapy in children born small for gestational age: An analysis of LG growth study data
title_sort long-term effectiveness of growth hormone therapy in children born small for gestational age: an analysis of lg growth study data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041836/
https://www.ncbi.nlm.nih.gov/pubmed/35472208
http://dx.doi.org/10.1371/journal.pone.0266329
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