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Efficacy assessment of a novel endolysin PlyAZ3a(T) for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model

BACKGROUND: Treatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including multi-drug resistant strains, making them attrac...

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Detalles Bibliográficos
Autores principales:	Valente, Luca G., Le, Ngoc Dung, Pitton, Melissa, Chiffi, Gabriele, Grandgirard, Denis, Jakob, Stephan M., Cameron, David R., Resch, Grégory, Que, Yok-Ai, Leib, Stephen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041855/ https://www.ncbi.nlm.nih.gov/pubmed/35472061 http://dx.doi.org/10.1371/journal.pone.0266928

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