Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided into a high-level overview of the types of proble...

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Autores principales: Kondic, Anna, Bottino, Dean, Harrold, John, Kearns, Jeffrey D., Musante, CJ, Odinecs, Aleksandrs, Ramanujan, Saroja, Selimkhanov, Jangir, Schoeberl, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042116/
https://www.ncbi.nlm.nih.gov/pubmed/35496315
http://dx.doi.org/10.3389/fphar.2022.860881
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author Kondic, Anna
Bottino, Dean
Harrold, John
Kearns, Jeffrey D.
Musante, CJ
Odinecs, Aleksandrs
Ramanujan, Saroja
Selimkhanov, Jangir
Schoeberl, Birgit
author_facet Kondic, Anna
Bottino, Dean
Harrold, John
Kearns, Jeffrey D.
Musante, CJ
Odinecs, Aleksandrs
Ramanujan, Saroja
Selimkhanov, Jangir
Schoeberl, Birgit
author_sort Kondic, Anna
collection PubMed
description The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided into a high-level overview of the types of problems that are being aided by modeling and simulation approaches, followed by detailed case studies around drug design (Nektar Therapeutics, Genentech), feasibility analysis (Novartis Pharmaceuticals), improvement of preclinical drug design (Pfizer), and preclinical to clinical extrapolation (Merck, Takeda, and Amgen).
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spelling pubmed-90421162022-04-27 Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making Kondic, Anna Bottino, Dean Harrold, John Kearns, Jeffrey D. Musante, CJ Odinecs, Aleksandrs Ramanujan, Saroja Selimkhanov, Jangir Schoeberl, Birgit Front Pharmacol Pharmacology The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided into a high-level overview of the types of problems that are being aided by modeling and simulation approaches, followed by detailed case studies around drug design (Nektar Therapeutics, Genentech), feasibility analysis (Novartis Pharmaceuticals), improvement of preclinical drug design (Pfizer), and preclinical to clinical extrapolation (Merck, Takeda, and Amgen). Frontiers Media S.A. 2022-04-12 /pmc/articles/PMC9042116/ /pubmed/35496315 http://dx.doi.org/10.3389/fphar.2022.860881 Text en Copyright © 2022 Kondic, Bottino, Harrold, Kearns, Musante, Odinecs, Ramanujan, Selimkhanov and Schoeberl. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kondic, Anna
Bottino, Dean
Harrold, John
Kearns, Jeffrey D.
Musante, CJ
Odinecs, Aleksandrs
Ramanujan, Saroja
Selimkhanov, Jangir
Schoeberl, Birgit
Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making
title Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making
title_full Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making
title_fullStr Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making
title_full_unstemmed Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making
title_short Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making
title_sort navigating between right, wrong, and relevant: the use of mathematical modeling in preclinical decision making
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042116/
https://www.ncbi.nlm.nih.gov/pubmed/35496315
http://dx.doi.org/10.3389/fphar.2022.860881
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