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Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses

Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implem...

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Autores principales: Bang, Jee Yoon, Sunstrum, Julia Kathryn, Garand, Danielle, Parfitt, Gustavo Morrone, Woodin, Melanie, Inoue, Wataru, Kim, Junchul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042231/
https://www.ncbi.nlm.nih.gov/pubmed/35420543
http://dx.doi.org/10.7554/eLife.74736
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author Bang, Jee Yoon
Sunstrum, Julia Kathryn
Garand, Danielle
Parfitt, Gustavo Morrone
Woodin, Melanie
Inoue, Wataru
Kim, Junchul
author_facet Bang, Jee Yoon
Sunstrum, Julia Kathryn
Garand, Danielle
Parfitt, Gustavo Morrone
Woodin, Melanie
Inoue, Wataru
Kim, Junchul
author_sort Bang, Jee Yoon
collection PubMed
description Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviors.
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spelling pubmed-90422312022-04-27 Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses Bang, Jee Yoon Sunstrum, Julia Kathryn Garand, Danielle Parfitt, Gustavo Morrone Woodin, Melanie Inoue, Wataru Kim, Junchul eLife Neuroscience Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviors. eLife Sciences Publications, Ltd 2022-04-14 /pmc/articles/PMC9042231/ /pubmed/35420543 http://dx.doi.org/10.7554/eLife.74736 Text en © 2022, Bang et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Bang, Jee Yoon
Sunstrum, Julia Kathryn
Garand, Danielle
Parfitt, Gustavo Morrone
Woodin, Melanie
Inoue, Wataru
Kim, Junchul
Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
title Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
title_full Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
title_fullStr Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
title_full_unstemmed Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
title_short Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
title_sort hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042231/
https://www.ncbi.nlm.nih.gov/pubmed/35420543
http://dx.doi.org/10.7554/eLife.74736
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