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Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implem...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042231/ https://www.ncbi.nlm.nih.gov/pubmed/35420543 http://dx.doi.org/10.7554/eLife.74736 |
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author | Bang, Jee Yoon Sunstrum, Julia Kathryn Garand, Danielle Parfitt, Gustavo Morrone Woodin, Melanie Inoue, Wataru Kim, Junchul |
author_facet | Bang, Jee Yoon Sunstrum, Julia Kathryn Garand, Danielle Parfitt, Gustavo Morrone Woodin, Melanie Inoue, Wataru Kim, Junchul |
author_sort | Bang, Jee Yoon |
collection | PubMed |
description | Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviors. |
format | Online Article Text |
id | pubmed-9042231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-90422312022-04-27 Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses Bang, Jee Yoon Sunstrum, Julia Kathryn Garand, Danielle Parfitt, Gustavo Morrone Woodin, Melanie Inoue, Wataru Kim, Junchul eLife Neuroscience Preys use their memory – where they sensed a predatory threat and whether a safe shelter is nearby – to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviors. eLife Sciences Publications, Ltd 2022-04-14 /pmc/articles/PMC9042231/ /pubmed/35420543 http://dx.doi.org/10.7554/eLife.74736 Text en © 2022, Bang et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Bang, Jee Yoon Sunstrum, Julia Kathryn Garand, Danielle Parfitt, Gustavo Morrone Woodin, Melanie Inoue, Wataru Kim, Junchul Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
title | Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
title_full | Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
title_fullStr | Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
title_full_unstemmed | Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
title_short | Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
title_sort | hippocampal-hypothalamic circuit controls context-dependent innate defensive responses |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042231/ https://www.ncbi.nlm.nih.gov/pubmed/35420543 http://dx.doi.org/10.7554/eLife.74736 |
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