Consecutive reactions to construct tricarbonyl compounds and synthetic applications thereof

Lithium anions derived from O-carbonate-protected cyanohydrins undergo conjugate addition to cycloalkenones with the concomitant transfer of the alkoxycarbonyl group to produce tricarbonyl compounds. These products offer numerous possibilities for further elaboration. The synthetic potential of the...

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Detalles Bibliográficos
Autores principales: Madroñero, Diego, Mujica-Martinez, Cesar A., Vázquez, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042245/
https://www.ncbi.nlm.nih.gov/pubmed/35497560
http://dx.doi.org/10.1039/d1ra05187c
Descripción
Sumario:Lithium anions derived from O-carbonate-protected cyanohydrins undergo conjugate addition to cycloalkenones with the concomitant transfer of the alkoxycarbonyl group to produce tricarbonyl compounds. These products offer numerous possibilities for further elaboration. The synthetic potential of the cascade products was demonstrated by forming bicyclic and tricyclic systems through intramolecular condensation reactions.

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