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Using dual exonucleases to finely distinguish structural adjustment of aptamers for small-molecule detection
The binding of small molecules to their DNA aptamers can modulate their susceptibility to digestion by exonucleases, however, absolute differentiation between digestion and inhibition has never been reported. Here, we show that the digestion of aptamers by T7 exonuclease can be completely inhibited...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042303/ https://www.ncbi.nlm.nih.gov/pubmed/35493548 http://dx.doi.org/10.1039/d1ra05551h |