Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron

Sterically shielded 1,2,4-trioxolanes prepared by Griesbaum co-ozonolysis have been utilized as chemical sensors of ferrous iron in several recently described chemical probes of labile iron. Here we report optimized conditions for co-ozonolysis that proceed efficiently and with high diastereoselecti...

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Detalles Bibliográficos
Autores principales: Chen, Jun, Gonciarz, Ryan L., Renslo, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042324/
https://www.ncbi.nlm.nih.gov/pubmed/35497286
http://dx.doi.org/10.1039/d1ra05932g
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author Chen, Jun
Gonciarz, Ryan L.
Renslo, Adam R.
author_facet Chen, Jun
Gonciarz, Ryan L.
Renslo, Adam R.
author_sort Chen, Jun
collection PubMed
description Sterically shielded 1,2,4-trioxolanes prepared by Griesbaum co-ozonolysis have been utilized as chemical sensors of ferrous iron in several recently described chemical probes of labile iron. Here we report optimized conditions for co-ozonolysis that proceed efficiently and with high diastereoselectivity across an expanded range of substrates, and should enable a new generation of labile iron probes with altered reaction kinetics and physicochemical properties.
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spelling pubmed-90423242022-04-28 Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron Chen, Jun Gonciarz, Ryan L. Renslo, Adam R. RSC Adv Chemistry Sterically shielded 1,2,4-trioxolanes prepared by Griesbaum co-ozonolysis have been utilized as chemical sensors of ferrous iron in several recently described chemical probes of labile iron. Here we report optimized conditions for co-ozonolysis that proceed efficiently and with high diastereoselectivity across an expanded range of substrates, and should enable a new generation of labile iron probes with altered reaction kinetics and physicochemical properties. The Royal Society of Chemistry 2021-10-22 /pmc/articles/PMC9042324/ /pubmed/35497286 http://dx.doi.org/10.1039/d1ra05932g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chen, Jun
Gonciarz, Ryan L.
Renslo, Adam R.
Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
title Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
title_full Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
title_fullStr Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
title_full_unstemmed Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
title_short Expanded scope of Griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
title_sort expanded scope of griesbaum co-ozonolysis for the preparation of structurally diverse sensors of ferrous iron
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042324/
https://www.ncbi.nlm.nih.gov/pubmed/35497286
http://dx.doi.org/10.1039/d1ra05932g
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AT rensloadamr expandedscopeofgriesbaumcoozonolysisforthepreparationofstructurallydiversesensorsofferrousiron

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