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Thrombin Induces COX-2 and PGE(2) Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells

The inflammation of the airway and lung could be triggered by upregulation cyclooxygenase (COX)-2 and prostaglandin E(2) (PGE(2)) induced by various proinflammatory factors. COX-2 induction by thrombin has been shown to play a vital role in various inflammatory diseases. However, in human tracheal s...

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Detalles Bibliográficos
Autores principales:	Yang, Chien-Chung, Hsiao, Li-Der, Shih, Ya-Fang, Hsu, Chih-Kai, Hu, Chia-Yu, Yang, Chuen-Mao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042634/ https://www.ncbi.nlm.nih.gov/pubmed/35497094 http://dx.doi.org/10.1155/2022/4600029

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