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A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis

PURPOSE: To compare the clinical profile of COVID-related and non-COVID-related rhino-orbito-cerebral invasive fungal disease. METHODS: We have compared the comorbidities, clinical features, course of the disease and outcome between COVID-related and non-COVID-related acute invasive fungal rhinosinu...

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Autores principales: Sebastian, Susan K., Ponnuvelu, Sahana, Sharma, Yukti, Jha, Rakhi Kuari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042656/
https://www.ncbi.nlm.nih.gov/pubmed/35476130
http://dx.doi.org/10.1007/s00405-022-07402-x
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author Sebastian, Susan K.
Ponnuvelu, Sahana
Sharma, Yukti
Jha, Rakhi Kuari
author_facet Sebastian, Susan K.
Ponnuvelu, Sahana
Sharma, Yukti
Jha, Rakhi Kuari
author_sort Sebastian, Susan K.
collection PubMed
description PURPOSE: To compare the clinical profile of COVID-related and non-COVID-related rhino-orbito-cerebral invasive fungal disease. METHODS: We have compared the comorbidities, clinical features, course of the disease and outcome between COVID-related and non-COVID-related acute invasive fungal rhinosinusitis (AIFRS) of the rhino-orbito-cerebral form. RESULTS: HbA1c and blood sugar at the time of admission were significantly higher in the non-COVID group (P < 0.05). Duration of stay, and use of steroids were significantly higher among the COVID group (P < 0.05). The period of hospital stay was significantly higher in the COVID group. The overall survival in the COVID group was 67.57%. In the non-COVID group the overall survival was 61.90%.This study found that odds of surgical treatment was significantly lower among non-survivors (P < 0.05). Similarly patients who developed stages 3 & 4 of the disease had a lower survival rate (P < 0.05). CONCLUSION: Diabetes mellitus is a key risk factor for the development of AIFRS. Pre-existing, grossly uncontrolled DM was the predisposing factor in the non-COVID group. Deranged glucose profile associated with COVID illness and its treatment and immunological disturbances in a vulnerable population, contributed to the surge in cases of AIFRS in the COVID-19-related group. Patients who underwent combined medical and surgical treatment had a significantly better outcome following AIFRS.
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spelling pubmed-90426562022-04-27 A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis Sebastian, Susan K. Ponnuvelu, Sahana Sharma, Yukti Jha, Rakhi Kuari Eur Arch Otorhinolaryngol Rhinology PURPOSE: To compare the clinical profile of COVID-related and non-COVID-related rhino-orbito-cerebral invasive fungal disease. METHODS: We have compared the comorbidities, clinical features, course of the disease and outcome between COVID-related and non-COVID-related acute invasive fungal rhinosinusitis (AIFRS) of the rhino-orbito-cerebral form. RESULTS: HbA1c and blood sugar at the time of admission were significantly higher in the non-COVID group (P < 0.05). Duration of stay, and use of steroids were significantly higher among the COVID group (P < 0.05). The period of hospital stay was significantly higher in the COVID group. The overall survival in the COVID group was 67.57%. In the non-COVID group the overall survival was 61.90%.This study found that odds of surgical treatment was significantly lower among non-survivors (P < 0.05). Similarly patients who developed stages 3 & 4 of the disease had a lower survival rate (P < 0.05). CONCLUSION: Diabetes mellitus is a key risk factor for the development of AIFRS. Pre-existing, grossly uncontrolled DM was the predisposing factor in the non-COVID group. Deranged glucose profile associated with COVID illness and its treatment and immunological disturbances in a vulnerable population, contributed to the surge in cases of AIFRS in the COVID-19-related group. Patients who underwent combined medical and surgical treatment had a significantly better outcome following AIFRS. Springer Berlin Heidelberg 2022-04-27 2022 /pmc/articles/PMC9042656/ /pubmed/35476130 http://dx.doi.org/10.1007/s00405-022-07402-x Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Rhinology
Sebastian, Susan K.
Ponnuvelu, Sahana
Sharma, Yukti
Jha, Rakhi Kuari
A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis
title A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis
title_full A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis
title_fullStr A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis
title_full_unstemmed A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis
title_short A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis
title_sort comparative study on the clinical profile of covid-related and non-covid-related acute invasive fungal rhino sinusitis
topic Rhinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042656/
https://www.ncbi.nlm.nih.gov/pubmed/35476130
http://dx.doi.org/10.1007/s00405-022-07402-x
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