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Pharmacophore modeling, docking and the integrated use of a ligand- and structure-based virtual screening approach for novel DNA gyrase inhibitors: synthetic and biological evaluation studies

Fluoroquinolones, a class of compound, act via inhibiting DNA gyrase and topoisomerase IV enzymes. This is an important class of drugs with high success rates for the treatment of tuberculosis and other bacterial infections. An indirect drug design approach was used to develop a meaningful pharmacop...

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Detalles Bibliográficos
Autores principales:	Mathpal, Deepti, Masand, Mukesh, Thomas, Anisha, Ahmad, Irfan, Saeed, Mohd, Zaman, Gaffar Sarwar, Kamal, Mehnaz, Jawaid, Talha, Sharma, Pramod K., Gupta, Madan M., Kumar, Santosh, Srivastava, Swayam Prakash, Balaramnavar, Vishal M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042709/ https://www.ncbi.nlm.nih.gov/pubmed/35494744 http://dx.doi.org/10.1039/d1ra05630a

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