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Myeloid-derived suppressor cells in COVID-19: A review

Coronavirus disease 2019 (COVID-19) is a potentially life-threatening infection characterized by excessive inflammation, coagulation disorders and organ damage. A dysregulated myeloid cell compartment is one of the most striking immunopathologic signatures of this newly emerged infection. A growing...

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Detalles Bibliográficos
Autores principales: Perfilyeva, Yuliya V., Ostapchuk, Yekaterina O., Tleulieva, Raikhan, Kali, Aykin, Abdolla, Nurshat, Krasnoshtanov, Vladimir K., Perfilyeva, Anastassiya V., Belyaev, Nikolai N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042722/
https://www.ncbi.nlm.nih.gov/pubmed/35489643
http://dx.doi.org/10.1016/j.clim.2022.109024
Descripción
Sumario:Coronavirus disease 2019 (COVID-19) is a potentially life-threatening infection characterized by excessive inflammation, coagulation disorders and organ damage. A dysregulated myeloid cell compartment is one of the most striking immunopathologic signatures of this newly emerged infection. A growing number of studies are reporting on the expansion of myeloid cells with immunoregulatory activities in the periphery and airways of COVID-19 patients. These cells share phenotypic and functional similarities with myeloid-derived suppressor cells (MDSCs), which were first described in cancer patients. MDSCs are a heterogeneous population of pathologically activated myeloid cells that exert immunosuppressive activities against mainly effector T cells. The increased frequency of these cells in COVID-19 patients suggests that they are involved in immune regulation during this infection. In this article, we review the current findings on MDSCs in COVID-19 and discuss the complex role of these cells in the immunopathology of COVID-19.