Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model

Spondylocarpotarsal syndrome (SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions resulting from biallelic nonsense mutations in the gene encoding filamin B (FLNB). Utilizing a FLNB knockout mouse, we showed that the vertebral fusions in S...

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Detalles Bibliográficos
Autores principales: Zieba, Jennifer, Forlenza, Kimberly N., Heard, Kelly, Martin, Jorge H., Bosakova, Michaela, Cohn, Daniel H., Robertson, Stephen P., Krejci, Pavel, Krakow, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042866/
https://www.ncbi.nlm.nih.gov/pubmed/35474298
http://dx.doi.org/10.1038/s41413-022-00200-5

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