T cell receptor and IL-2 signaling strength control memory CD8(+) T cell functional fitness via chromatin remodeling

Cognate antigen signal controls CD8(+) T cell priming, expansion size and effector versus memory cell fates, but it is not known if and how it modulates the functional features of memory CD8(+) T cells. Here we show that the strength of T cell receptor (TCR) signaling controls the requirement for in...

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Detalles Bibliográficos
Autores principales: Chin, Shu Shien, Guillen, Erik, Chorro, Laurent, Achar, Sooraj, Ng, Karina, Oberle, Susanne, Alfei, Francesca, Zehn, Dietmar, Altan-Bonnet, Grégoire, Delahaye, Fabien, Lauvau, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042912/
https://www.ncbi.nlm.nih.gov/pubmed/35474218
http://dx.doi.org/10.1038/s41467-022-29718-2

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