Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association

Ebola virus (EBOV), one of the deadliest viruses, is the cause of fatal Ebola virus disease (EVD). The underlying mechanism of viral replication and EBOV-related hemorrhage is not fully understood. Here, we show that EBOV VP35, a cofactor of viral RNA-dependent RNA polymerase, binds human A kinase i...

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Detalles Bibliográficos
Autores principales: Zhu, Lin, Gao, Ting, Huang, Yi, Jin, Jing, Wang, Di, Zhang, Leike, Jin, Yanwen, Li, Ping, Hu, Yong, Wu, Yan, Liu, Hainan, Dong, Qincai, Wang, Guangfei, Zheng, Tong, Song, Caiwei, Bai, Yu, Zhang, Xun, Liu, Yaoning, Yang, Weihong, Xu, Ke, Zou, Gang, Zhao, Lei, Cao, Ruiyuan, Zhong, Wu, Xia, Xianzhu, Xiao, Gengfu, Liu, Xuan, Cao, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042921/
https://www.ncbi.nlm.nih.gov/pubmed/35474062
http://dx.doi.org/10.1038/s41467-022-29948-4

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