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Utility of High Resolution 2D NMR Fingerprinting in Assessing Viscosity of Therapeutic Monoclonal Antibodies

PURPOSE: The viscosity of highly concentrated therapeutic monoclonal antibody (mAb) formulations at concentrations ≥ 100 mg/mL can significantly affect the stability, processing, and drug product development for subcutaneous delivery. An early identification of a viscosity prone mAb during candidate...

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Detalles Bibliográficos
Autores principales:	Majumder, Subhabrata, Bhattacharya, Deep S., Langford, Alex, Ignatius, Arun Alphonse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043092/ https://www.ncbi.nlm.nih.gov/pubmed/35174433 http://dx.doi.org/10.1007/s11095-022-03200-6

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