Function and Therapeutic Implications of tRNA Derived Small RNAs

tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gen...

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Detalles Bibliográficos
Autores principales: Wilson, Briana, Dutta, Anindya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043108/
https://www.ncbi.nlm.nih.gov/pubmed/35495621
http://dx.doi.org/10.3389/fmolb.2022.888424
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author Wilson, Briana
Dutta, Anindya
author_facet Wilson, Briana
Dutta, Anindya
author_sort Wilson, Briana
collection PubMed
description tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential.
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spelling pubmed-90431082022-04-28 Function and Therapeutic Implications of tRNA Derived Small RNAs Wilson, Briana Dutta, Anindya Front Mol Biosci Molecular Biosciences tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from nascent RNA silencing, to post-transcriptional gene silencing, and finally, to translational regulation. The length distribution, sequence diversity, and multifaceted functions of tRFs and tiRs positions them as attractive new models for small RNA therapeutics. In this review, we will discuss the principles of tRF biogenesis and function in order to highlight their therapeutic potential. Frontiers Media S.A. 2022-04-13 /pmc/articles/PMC9043108/ /pubmed/35495621 http://dx.doi.org/10.3389/fmolb.2022.888424 Text en Copyright © 2022 Wilson and Dutta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Wilson, Briana
Dutta, Anindya
Function and Therapeutic Implications of tRNA Derived Small RNAs
title Function and Therapeutic Implications of tRNA Derived Small RNAs
title_full Function and Therapeutic Implications of tRNA Derived Small RNAs
title_fullStr Function and Therapeutic Implications of tRNA Derived Small RNAs
title_full_unstemmed Function and Therapeutic Implications of tRNA Derived Small RNAs
title_short Function and Therapeutic Implications of tRNA Derived Small RNAs
title_sort function and therapeutic implications of trna derived small rnas
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043108/
https://www.ncbi.nlm.nih.gov/pubmed/35495621
http://dx.doi.org/10.3389/fmolb.2022.888424
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