Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after my...

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Autores principales: Varzideh, Fahimeh, Kansakar, Urna, Donkor, Kwame, Wilson, Scott, Jankauskas, Stanislovas S., Mone, Pasquale, Wang, Xujun, Lombardi, Angela, Santulli, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043126/
https://www.ncbi.nlm.nih.gov/pubmed/35498051
http://dx.doi.org/10.3389/fcvm.2022.863238
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author Varzideh, Fahimeh
Kansakar, Urna
Donkor, Kwame
Wilson, Scott
Jankauskas, Stanislovas S.
Mone, Pasquale
Wang, Xujun
Lombardi, Angela
Santulli, Gaetano
author_facet Varzideh, Fahimeh
Kansakar, Urna
Donkor, Kwame
Wilson, Scott
Jankauskas, Stanislovas S.
Mone, Pasquale
Wang, Xujun
Lombardi, Angela
Santulli, Gaetano
author_sort Varzideh, Fahimeh
collection PubMed
description After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.
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spelling pubmed-90431262022-04-28 Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis Varzideh, Fahimeh Kansakar, Urna Donkor, Kwame Wilson, Scott Jankauskas, Stanislovas S. Mone, Pasquale Wang, Xujun Lombardi, Angela Santulli, Gaetano Front Cardiovasc Med Cardiovascular Medicine After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields. Frontiers Media S.A. 2022-04-13 /pmc/articles/PMC9043126/ /pubmed/35498051 http://dx.doi.org/10.3389/fcvm.2022.863238 Text en Copyright © 2022 Varzideh, Kansakar, Donkor, Wilson, Jankauskas, Mone, Wang, Lombardi and Santulli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Varzideh, Fahimeh
Kansakar, Urna
Donkor, Kwame
Wilson, Scott
Jankauskas, Stanislovas S.
Mone, Pasquale
Wang, Xujun
Lombardi, Angela
Santulli, Gaetano
Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
title Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
title_full Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
title_fullStr Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
title_full_unstemmed Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
title_short Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis
title_sort cardiac remodeling after myocardial infarction: functional contribution of micrornas to inflammation and fibrosis
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043126/
https://www.ncbi.nlm.nih.gov/pubmed/35498051
http://dx.doi.org/10.3389/fcvm.2022.863238
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