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p53 and Zinc: A Malleable Relationship

A large percentage of transcription factors require zinc to bind DNA. In this review, we discuss what makes p53 unique among zinc-dependent transcription factors. The conformation of p53 is unusually malleable: p53 binds zinc extremely tightly when folded, but is intrinsically unstable in the absenc...

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Detalles Bibliográficos
Autores principales:	Ha, Jeung-Hoi, Prela, Orjola, Carpizo, Darren R., Loh, Stewart N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043292/ https://www.ncbi.nlm.nih.gov/pubmed/35495631 http://dx.doi.org/10.3389/fmolb.2022.895887

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