Cargando…

SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection

Zika virus (ZIKV) is a neurotropic flavivirus recently linked to congenital ZIKV syndrome in children and encephalitis and Guillain-Barré syndrome in adults. Neurotropic viruses often use axons to traffic to neuronal or glial cell somas where they either remain latent or replicate and proceed to inf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crawford, Colin L., Antoniou, Christina, Komarek, Lina, Schultz, Verena, Donald, Claire L., Montague, Paul, Barnett, Susan C., Linington, Christopher, Willison, Hugh J., Kohl, Alain, Coleman, Michael P., Edgar, Julia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043327/ https://www.ncbi.nlm.nih.gov/pubmed/35493328 http://dx.doi.org/10.3389/fnmol.2022.860410

Ejemplares similares

Zika Virus Infection Leads to Demyelination and Axonal Injury in Mature CNS Cultures
por: Schultz, Verena, et al.
Publicado: (2021)

Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for CNS complications
por: Schultz, Verena, et al.
Publicado: (2021)

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice
por: Fazal, Shaline V., et al.
Publicado: (2023)

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion
por: Sasaki, Yo, et al.
Publicado: (2016)

Multifaceted roles of SARM1 in axon degeneration and signaling
por: Waller, Thomas J., et al.
Publicado: (2022)

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
por: Loreto, Andrea, et al.
Publicado: (2021)

TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration
por: Czech, Victoria L, et al.
Publicado: (2023)

The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila
por: Llobet Rosell, Arnau, et al.
Publicado: (2022)

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
por: Loreto, Andrea, et al.
Publicado: (2020)

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
por: Gilley, Jonathan, et al.
Publicado: (2015)

Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies
por: Sundaramoorthy, Vinod, et al.
Publicado: (2020)

A good gut feeling on Sarm1-mediated axon degeneration
por: von Saucken, Victoria E., et al.
Publicado: (2021)

SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease
por: Lai, Meng-Yu, et al.
Publicado: (2022)

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
por: Gould, Stacey Anne, et al.
Publicado: (2021)

Small Molecule SARM1 Inhibitors Recapitulate the SARM1(−/−) Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
por: Hughes, Robert O., et al.
Publicado: (2021)

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice
por: Geisler, Stefanie, et al.
Publicado: (2019)

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
por: Ko, Kwang Woo, et al.
Publicado: (2020)

SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
por: Ketschek, Andrea, et al.
Publicado: (2022)

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected
por: Cumberworth, Stephanie L., et al.
Publicado: (2017)

Macrophage depletion blocks congenital SARM1-dependent neuropathy
por: Dingwall, Caitlin B., et al.
Publicado: (2022)

Sarm1 activation produces cADPR to increase intra-axonal Ca(++) and promote axon degeneration in PIPN
por: Li, Yihang, et al.
Publicado: (2021)

Blocking Wallerian degeneration by loss of Sarm1 does not promote axon resealing in zebrafish
por: Tian, Weili, et al.
Publicado: (2020)

Heparanase attenuates axon degeneration following sciatic nerve transection
por: Whitehead, Michael J., et al.
Publicado: (2018)

SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
por: Sasaki, Yo, et al.
Publicado: (2020)

Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis
por: Viar, Kenneth, et al.
Publicado: (2020)

Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration
por: Tian, Weili, et al.
Publicado: (2020)

Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival
por: Ademi, Mirlinda, et al.
Publicado: (2022)

Glia Expression of MHC During CNS Infection by Neurotropic Coronavirus
por: Malone, Karen E., et al.
Publicado: (2006)

Autophagy protein ULK1 interacts with and regulates SARM1 during axonal injury
por: Choi, Harry M. C., et al.
Publicado: (2022)

Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves
por: Perlman, Stanley, et al.
Publicado: (1989)

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy
por: Bosanac, Todd, et al.
Publicado: (2021)

Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy
por: Alexandris, Athanasios S., et al.
Publicado: (2023)

Axonal degeneration as a therapeutic target in the CNS
por: Lingor, Paul, et al.
Publicado: (2012)

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans
por: Khazma, Tami, et al.
Publicado: (2023)

Necroptosis is SARMful to your health
por: Pierchala, Brian A.
Publicado: (2020)

Traumatic axonopathy in spinal tracts after impact acceleration head injury: Ultrastructural observations and evidence of SARM1-dependent axonal degeneration
por: Alexandris, Athanasios S., et al.
Publicado: (2023)

Subcapsular Sinus Macrophages Prevent CNS Invasion Upon Peripheral Infection With a Neurotropic Virus
por: Iannacone, Matteo, et al.
Publicado: (2010)

Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling
por: Jin, Lingting, et al.
Publicado: (2022)

Human endothelial cells secrete neurotropic factors to direct axonal growth of peripheral nerves
por: Grasman, Jonathan M., et al.
Publicado: (2017)

The Use of Myelinating Cultures as a Screen of Glycomolecules for CNS Repair
por: McCanney, George A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tuhc2bnvl4s6i16m0ddb8fpir5