Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose

An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N(4)-acetyl cytosine, to an amidoxime. This method...

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Detalles Bibliográficos
Autores principales: Ahmed, Ajaz, Ahmed, Qazi Naveed, Mukherjee, Debaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043332/
https://www.ncbi.nlm.nih.gov/pubmed/35492778
http://dx.doi.org/10.1039/d1ra06912h
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author Ahmed, Ajaz
Ahmed, Qazi Naveed
Mukherjee, Debaraj
author_facet Ahmed, Ajaz
Ahmed, Qazi Naveed
Mukherjee, Debaraj
author_sort Ahmed, Ajaz
collection PubMed
description An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N(4)-acetyl cytosine, to an amidoxime. This method avoids use of expensive starting materials, enzymes, complex reagents, and cumbersome purification procedures.
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spelling pubmed-90433322022-04-28 Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose Ahmed, Ajaz Ahmed, Qazi Naveed Mukherjee, Debaraj RSC Adv Chemistry An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N(4)-acetyl cytosine, to an amidoxime. This method avoids use of expensive starting materials, enzymes, complex reagents, and cumbersome purification procedures. The Royal Society of Chemistry 2021-11-10 /pmc/articles/PMC9043332/ /pubmed/35492778 http://dx.doi.org/10.1039/d1ra06912h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Ahmed, Ajaz
Ahmed, Qazi Naveed
Mukherjee, Debaraj
Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
title Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
title_full Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
title_fullStr Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
title_full_unstemmed Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
title_short Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
title_sort conversion of n-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (eidd-2801) from ribose
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043332/
https://www.ncbi.nlm.nih.gov/pubmed/35492778
http://dx.doi.org/10.1039/d1ra06912h
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AT mukherjeedebaraj conversionofnacylamidinestoamidoximesaconvenientsyntheticapproachtomolnupiravireidd2801fromribose

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