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Effect of monovalent salt concentration and peptide secondary structure in peptide-micelle binding

Recently, we reported a cationic 14 residue peptide LL-14 (LKWLKKLLKWLKKL) with salt-sensitive broad-spectrum antimicrobial potency. However, the mechanism of its salt (NaCl) sensitivity remained unclear. In this study, we have reported computational (∼14.2 μs of MD) and experimental (CD, fluorescen...

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Detalles Bibliográficos
Autores principales: Ghosh, Suvankar, Pandit, Gopal, Debnath, Swapna, Chatterjee, Sunanda, Satpati, Priyadarshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043568/
https://www.ncbi.nlm.nih.gov/pubmed/35494385
http://dx.doi.org/10.1039/d1ra06772a