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Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors

INTRODUCTION: Prostate cancer treatment has established effects on the health-related quality of life (HRQOL) of patients. While racial/ethnic differences in HRQOL have been explored in heterosexual patients, this is the first study to examine racial/ethnic differences in a cohort of sexual minority...

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Autores principales: Bates, Alex J., Rosser, B. R. Simon, Polter, Elizabeth J., Wheldon, Christopher W., Talley, Kristine M. C., Haggart, Ryan, Wright, Morgan, Mitteldorf, Darryl, West, William, Ross, Michael W., Konety, Badrinath R., Kohli, Nidhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043609/
https://www.ncbi.nlm.nih.gov/pubmed/35494011
http://dx.doi.org/10.3389/fonc.2022.833197
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author Bates, Alex J.
Rosser, B. R. Simon
Polter, Elizabeth J.
Wheldon, Christopher W.
Talley, Kristine M. C.
Haggart, Ryan
Wright, Morgan
Mitteldorf, Darryl
West, William
Ross, Michael W.
Konety, Badrinath R.
Kohli, Nidhi
author_facet Bates, Alex J.
Rosser, B. R. Simon
Polter, Elizabeth J.
Wheldon, Christopher W.
Talley, Kristine M. C.
Haggart, Ryan
Wright, Morgan
Mitteldorf, Darryl
West, William
Ross, Michael W.
Konety, Badrinath R.
Kohli, Nidhi
author_sort Bates, Alex J.
collection PubMed
description INTRODUCTION: Prostate cancer treatment has established effects on the health-related quality of life (HRQOL) of patients. While racial/ethnic differences in HRQOL have been explored in heterosexual patients, this is the first study to examine racial/ethnic differences in a cohort of sexual minority prostate cancer survivors. METHODS: We used data from the Restore-1 study, an online cross-sectional survey of sexual and gender minority (SGM) prostate cancer survivors in North America, to explore the association between race/ethnicity and HRQOL. General mental and physical HRQOL was assessed using the Short-Form Health Survey version 2 (SF-12). The frequency and distress of prostate cancer specific symptoms was assessed using the Expanded Prostate Cancer Composite (EPIC) scale. Multivariable linear regression was used to estimate mean differences in HRQOL between sexual minority men of color and their white, non-Hispanic counterparts after adjustment for pertinent demographic and medical characteristics. RESULTS: Among 190 participants, 23 (12%) self-identified as non-white and/or Hispanic. In unadjusted analysis, sexual minority men of color compared to their white counterparts reported worse HRQOL scores in the EPIC hormonal summary (73.8 vs. 81.8) and hormonal function (70.9 vs 80.5) domains. Clinically important differences between men of color and their white counterparts were seen in the EPIC bowel function (mean difference (MD): -4.5, 95% CI: -9.9, 0.8), hormonal summary (MD: -8.0, 95% CI: -15.6, -0.4), hormonal function (MD: -9.6, 95% CI: -17.6, -1.6), and hormonal bother (MD: -6.7, 95% CI: -14.4, 1.1) domains. After adjustment for covariates, clinically important differences persisted between men of color and white, non-Hispanic men on the hormonal summary (74.4 vs. 81.7), hormonal function (71.3 vs. 80.3), and hormonal bother (77.0 vs. 82.7) domains. CONCLUSIONS: This exploratory study provides the first evidence that sexual minority men of color may have worse HRQOL outcomes compared to white, non-Hispanic sexual minority men following prostate cancer treatment.
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spelling pubmed-90436092022-04-28 Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors Bates, Alex J. Rosser, B. R. Simon Polter, Elizabeth J. Wheldon, Christopher W. Talley, Kristine M. C. Haggart, Ryan Wright, Morgan Mitteldorf, Darryl West, William Ross, Michael W. Konety, Badrinath R. Kohli, Nidhi Front Oncol Oncology INTRODUCTION: Prostate cancer treatment has established effects on the health-related quality of life (HRQOL) of patients. While racial/ethnic differences in HRQOL have been explored in heterosexual patients, this is the first study to examine racial/ethnic differences in a cohort of sexual minority prostate cancer survivors. METHODS: We used data from the Restore-1 study, an online cross-sectional survey of sexual and gender minority (SGM) prostate cancer survivors in North America, to explore the association between race/ethnicity and HRQOL. General mental and physical HRQOL was assessed using the Short-Form Health Survey version 2 (SF-12). The frequency and distress of prostate cancer specific symptoms was assessed using the Expanded Prostate Cancer Composite (EPIC) scale. Multivariable linear regression was used to estimate mean differences in HRQOL between sexual minority men of color and their white, non-Hispanic counterparts after adjustment for pertinent demographic and medical characteristics. RESULTS: Among 190 participants, 23 (12%) self-identified as non-white and/or Hispanic. In unadjusted analysis, sexual minority men of color compared to their white counterparts reported worse HRQOL scores in the EPIC hormonal summary (73.8 vs. 81.8) and hormonal function (70.9 vs 80.5) domains. Clinically important differences between men of color and their white counterparts were seen in the EPIC bowel function (mean difference (MD): -4.5, 95% CI: -9.9, 0.8), hormonal summary (MD: -8.0, 95% CI: -15.6, -0.4), hormonal function (MD: -9.6, 95% CI: -17.6, -1.6), and hormonal bother (MD: -6.7, 95% CI: -14.4, 1.1) domains. After adjustment for covariates, clinically important differences persisted between men of color and white, non-Hispanic men on the hormonal summary (74.4 vs. 81.7), hormonal function (71.3 vs. 80.3), and hormonal bother (77.0 vs. 82.7) domains. CONCLUSIONS: This exploratory study provides the first evidence that sexual minority men of color may have worse HRQOL outcomes compared to white, non-Hispanic sexual minority men following prostate cancer treatment. Frontiers Media S.A. 2022-04-13 /pmc/articles/PMC9043609/ /pubmed/35494011 http://dx.doi.org/10.3389/fonc.2022.833197 Text en Copyright © 2022 Bates, Rosser, Polter, Wheldon, Talley, Haggart, Wright, Mitteldorf, West, Ross, Konety and Kohli https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bates, Alex J.
Rosser, B. R. Simon
Polter, Elizabeth J.
Wheldon, Christopher W.
Talley, Kristine M. C.
Haggart, Ryan
Wright, Morgan
Mitteldorf, Darryl
West, William
Ross, Michael W.
Konety, Badrinath R.
Kohli, Nidhi
Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
title Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
title_full Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
title_fullStr Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
title_full_unstemmed Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
title_short Racial/Ethnic Differences in Health-Related Quality of Life Among Gay and Bisexual Prostate Cancer Survivors
title_sort racial/ethnic differences in health-related quality of life among gay and bisexual prostate cancer survivors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043609/
https://www.ncbi.nlm.nih.gov/pubmed/35494011
http://dx.doi.org/10.3389/fonc.2022.833197
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