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Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent

Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autis...

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Autores principales: Usui, Noriyoshi, Matsumoto-Miyai, Kazumasa, Koyama, Yoshihisa, Kobayashi, Yuki, Nakamura, Yukiko, Kobayashi, Hikaru, Shimada, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043691/
https://www.ncbi.nlm.nih.gov/pubmed/35492705
http://dx.doi.org/10.3389/fpsyt.2022.872302
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author Usui, Noriyoshi
Matsumoto-Miyai, Kazumasa
Koyama, Yoshihisa
Kobayashi, Yuki
Nakamura, Yukiko
Kobayashi, Hikaru
Shimada, Shoichi
author_facet Usui, Noriyoshi
Matsumoto-Miyai, Kazumasa
Koyama, Yoshihisa
Kobayashi, Yuki
Nakamura, Yukiko
Kobayashi, Hikaru
Shimada, Shoichi
author_sort Usui, Noriyoshi
collection PubMed
description Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we have developed a silicon (Si)-based hydrogen-producing antioxidant (Si-based agent) that continuously and effectively produces hydrogen in the body. Medical hydrogen is known to have antioxidative, anti-inflammatory, and antiapoptotic effects, therefore we applied our Si-based agent as a potential therapeutic agent to MIA. Using a MIA mouse model, we found that the Si-based agent improved the social communication of MIA offspring mice. We also found that the Si-based agent suppressed the expressions of inflammation-associated genes Ifna1 and Il-6 in the mouse brain. These results demonstrate that the Si-based agent is an effective prophylactic agent against MIA during pregnancy, suggesting that our Si-based agent may be a preventative or therapeutic agent for ASD and other disease risks in child health suppressing MIA damage.
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spelling pubmed-90436912022-04-28 Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent Usui, Noriyoshi Matsumoto-Miyai, Kazumasa Koyama, Yoshihisa Kobayashi, Yuki Nakamura, Yukiko Kobayashi, Hikaru Shimada, Shoichi Front Psychiatry Psychiatry Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we have developed a silicon (Si)-based hydrogen-producing antioxidant (Si-based agent) that continuously and effectively produces hydrogen in the body. Medical hydrogen is known to have antioxidative, anti-inflammatory, and antiapoptotic effects, therefore we applied our Si-based agent as a potential therapeutic agent to MIA. Using a MIA mouse model, we found that the Si-based agent improved the social communication of MIA offspring mice. We also found that the Si-based agent suppressed the expressions of inflammation-associated genes Ifna1 and Il-6 in the mouse brain. These results demonstrate that the Si-based agent is an effective prophylactic agent against MIA during pregnancy, suggesting that our Si-based agent may be a preventative or therapeutic agent for ASD and other disease risks in child health suppressing MIA damage. Frontiers Media S.A. 2022-04-13 /pmc/articles/PMC9043691/ /pubmed/35492705 http://dx.doi.org/10.3389/fpsyt.2022.872302 Text en Copyright © 2022 Usui, Matsumoto-Miyai, Koyama, Kobayashi, Nakamura, Kobayashi and Shimada. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Usui, Noriyoshi
Matsumoto-Miyai, Kazumasa
Koyama, Yoshihisa
Kobayashi, Yuki
Nakamura, Yukiko
Kobayashi, Hikaru
Shimada, Shoichi
Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent
title Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent
title_full Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent
title_fullStr Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent
title_full_unstemmed Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent
title_short Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent
title_sort social communication of maternal immune activation-affected offspring is improved by si-based hydrogen-producing agent
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043691/
https://www.ncbi.nlm.nih.gov/pubmed/35492705
http://dx.doi.org/10.3389/fpsyt.2022.872302
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