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Histone Methyltransferase DOT1L as a Promising Epigenetic Target for Treatment of Solid Tumors

The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is responsible for the epigenetic regulation of gene expression through specific methylation of lysine79 residue of histone H3 (H3K79) in actively transcribed genes. Its normal activity is crucial for embryonic d...

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Detalles Bibliográficos
Autores principales:	Alexandrova, Elena, Salvati, Annamaria, Pecoraro, Giovanni, Lamberti, Jessica, Melone, Viola, Sellitto, Assunta, Rizzo, Francesca, Giurato, Giorgio, Tarallo, Roberta, Nassa, Giovanni, Weisz, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043692/ https://www.ncbi.nlm.nih.gov/pubmed/35495127 http://dx.doi.org/10.3389/fgene.2022.864612

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