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The unappreciated generative role of cell movements in pattern formation
The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043703/ https://www.ncbi.nlm.nih.gov/pubmed/35601454 http://dx.doi.org/10.1098/rsos.211293 |
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author | Fulton, Timothy Verd, Berta Steventon, Benjamin |
author_facet | Fulton, Timothy Verd, Berta Steventon, Benjamin |
author_sort | Fulton, Timothy |
collection | PubMed |
description | The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint. |
format | Online Article Text |
id | pubmed-9043703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-90437032022-05-21 The unappreciated generative role of cell movements in pattern formation Fulton, Timothy Verd, Berta Steventon, Benjamin R Soc Open Sci Biochemistry, Cellular and Molecular Biology The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint. The Royal Society 2022-04-27 /pmc/articles/PMC9043703/ /pubmed/35601454 http://dx.doi.org/10.1098/rsos.211293 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Biochemistry, Cellular and Molecular Biology Fulton, Timothy Verd, Berta Steventon, Benjamin The unappreciated generative role of cell movements in pattern formation |
title | The unappreciated generative role of cell movements in pattern formation |
title_full | The unappreciated generative role of cell movements in pattern formation |
title_fullStr | The unappreciated generative role of cell movements in pattern formation |
title_full_unstemmed | The unappreciated generative role of cell movements in pattern formation |
title_short | The unappreciated generative role of cell movements in pattern formation |
title_sort | unappreciated generative role of cell movements in pattern formation |
topic | Biochemistry, Cellular and Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043703/ https://www.ncbi.nlm.nih.gov/pubmed/35601454 http://dx.doi.org/10.1098/rsos.211293 |
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