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The unappreciated generative role of cell movements in pattern formation

The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cel...

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Detalles Bibliográficos
Autores principales: Fulton, Timothy, Verd, Berta, Steventon, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043703/
https://www.ncbi.nlm.nih.gov/pubmed/35601454
http://dx.doi.org/10.1098/rsos.211293
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author Fulton, Timothy
Verd, Berta
Steventon, Benjamin
author_facet Fulton, Timothy
Verd, Berta
Steventon, Benjamin
author_sort Fulton, Timothy
collection PubMed
description The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint.
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spelling pubmed-90437032022-05-21 The unappreciated generative role of cell movements in pattern formation Fulton, Timothy Verd, Berta Steventon, Benjamin R Soc Open Sci Biochemistry, Cellular and Molecular Biology The mechanisms underpinning the formation of patterned cellular landscapes has been the subject of extensive study as a fundamental problem of developmental biology. In most cases, attention has been given to situations in which cell movements are negligible, allowing researchers to focus on the cell-extrinsic signalling mechanisms, and intrinsic gene regulatory interactions that lead to pattern emergence at the tissue level. However, in many scenarios during development, cells rapidly change their neighbour relationships in order to drive tissue morphogenesis, while also undergoing patterning. To draw attention to the ubiquity of this problem and propose methodologies that will accommodate morphogenesis into the study of pattern formation, we review the current approaches to studying pattern formation in both static and motile cellular environments. We then consider how the cell movements themselves may contribute to the generation of pattern, rather than hinder it, with both a species specific and evolutionary viewpoint. The Royal Society 2022-04-27 /pmc/articles/PMC9043703/ /pubmed/35601454 http://dx.doi.org/10.1098/rsos.211293 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Biochemistry, Cellular and Molecular Biology
Fulton, Timothy
Verd, Berta
Steventon, Benjamin
The unappreciated generative role of cell movements in pattern formation
title The unappreciated generative role of cell movements in pattern formation
title_full The unappreciated generative role of cell movements in pattern formation
title_fullStr The unappreciated generative role of cell movements in pattern formation
title_full_unstemmed The unappreciated generative role of cell movements in pattern formation
title_short The unappreciated generative role of cell movements in pattern formation
title_sort unappreciated generative role of cell movements in pattern formation
topic Biochemistry, Cellular and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043703/
https://www.ncbi.nlm.nih.gov/pubmed/35601454
http://dx.doi.org/10.1098/rsos.211293
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