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Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis

OBJECTIVE: Septic peritonitis is associated with significant morbidity and mortality. As a potential therapeutic agent in the treatment of sepsis, 2-O, 3-O desulfated heparin (ODSH) reduces histones and platelet factor 4 (PF4) in mouse sepsis models. This pilot clinical trial evaluated the safety an...

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Detalles Bibliográficos
Autores principales:	Mauro, Katie D., Lambert, Michele P., Kowalska, M. Anna, Thawley, Vincent J., Poncz, Mortimer, Otto, Cynthia M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Veterinary Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043859/ https://www.ncbi.nlm.nih.gov/pubmed/35498738 http://dx.doi.org/10.3389/fvets.2022.862308

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