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Vascular cognitive impairment and dementia: An early career researcher perspective

The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the detrimental effects of vascular disease burden in the human brain. In this perspective piece, early career researchers...

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Autores principales: Silva, Nárlon C. Boa Sorte, Bracko, Oliver, Nelson, Amy R., de Oliveira, Fabricio Ferreira, Robison, Lisa S., Shaaban, C. Elizabeth, Hainsworth, Atticus H., Price, Brittani R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043906/
https://www.ncbi.nlm.nih.gov/pubmed/35496373
http://dx.doi.org/10.1002/dad2.12310
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author Silva, Nárlon C. Boa Sorte
Bracko, Oliver
Nelson, Amy R.
de Oliveira, Fabricio Ferreira
Robison, Lisa S.
Shaaban, C. Elizabeth
Hainsworth, Atticus H.
Price, Brittani R.
author_facet Silva, Nárlon C. Boa Sorte
Bracko, Oliver
Nelson, Amy R.
de Oliveira, Fabricio Ferreira
Robison, Lisa S.
Shaaban, C. Elizabeth
Hainsworth, Atticus H.
Price, Brittani R.
author_sort Silva, Nárlon C. Boa Sorte
collection PubMed
description The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the detrimental effects of vascular disease burden in the human brain. In this perspective piece, early career researchers (ECRs) in the field provide an overview of VCID, discuss past and present efforts, and highlight priorities for future research. We emphasize the following critical points as the field progresses: (a) consolidate existing neuroimaging and fluid biomarkers, and establish their utility for pharmacological and non‐pharmacological interventions; (b) develop new biomarkers, and new non‐clinical models that better recapitulate vascular pathologies; (c) amplify access to emerging biomarker and imaging techniques; (d) validate findings from previous investigations in diverse populations, including those at higher risk of cognitive impairment (e.g., Black, Hispanic, and Indigenous populations); and (e) conduct randomized controlled trials within diverse populations with well‐characterized vascular pathologies emphasizing clinically meaningful outcomes.
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spelling pubmed-90439062022-04-28 Vascular cognitive impairment and dementia: An early career researcher perspective Silva, Nárlon C. Boa Sorte Bracko, Oliver Nelson, Amy R. de Oliveira, Fabricio Ferreira Robison, Lisa S. Shaaban, C. Elizabeth Hainsworth, Atticus H. Price, Brittani R. Alzheimers Dement (Amst) Perspective The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the detrimental effects of vascular disease burden in the human brain. In this perspective piece, early career researchers (ECRs) in the field provide an overview of VCID, discuss past and present efforts, and highlight priorities for future research. We emphasize the following critical points as the field progresses: (a) consolidate existing neuroimaging and fluid biomarkers, and establish their utility for pharmacological and non‐pharmacological interventions; (b) develop new biomarkers, and new non‐clinical models that better recapitulate vascular pathologies; (c) amplify access to emerging biomarker and imaging techniques; (d) validate findings from previous investigations in diverse populations, including those at higher risk of cognitive impairment (e.g., Black, Hispanic, and Indigenous populations); and (e) conduct randomized controlled trials within diverse populations with well‐characterized vascular pathologies emphasizing clinically meaningful outcomes. John Wiley and Sons Inc. 2022-04-27 /pmc/articles/PMC9043906/ /pubmed/35496373 http://dx.doi.org/10.1002/dad2.12310 Text en © 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspective
Silva, Nárlon C. Boa Sorte
Bracko, Oliver
Nelson, Amy R.
de Oliveira, Fabricio Ferreira
Robison, Lisa S.
Shaaban, C. Elizabeth
Hainsworth, Atticus H.
Price, Brittani R.
Vascular cognitive impairment and dementia: An early career researcher perspective
title Vascular cognitive impairment and dementia: An early career researcher perspective
title_full Vascular cognitive impairment and dementia: An early career researcher perspective
title_fullStr Vascular cognitive impairment and dementia: An early career researcher perspective
title_full_unstemmed Vascular cognitive impairment and dementia: An early career researcher perspective
title_short Vascular cognitive impairment and dementia: An early career researcher perspective
title_sort vascular cognitive impairment and dementia: an early career researcher perspective
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043906/
https://www.ncbi.nlm.nih.gov/pubmed/35496373
http://dx.doi.org/10.1002/dad2.12310
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