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Recent applications of solid-phase strategy in total synthesis of antibiotics
Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043915/ https://www.ncbi.nlm.nih.gov/pubmed/35498098 http://dx.doi.org/10.1039/d1ra07503a |
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author | Zhou, Yuxin Liang, Xiao-Wei |
author_facet | Zhou, Yuxin Liang, Xiao-Wei |
author_sort | Zhou, Yuxin |
collection | PubMed |
description | Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established to search for existing antibiotics-based next-generation drug candidates that can conquer the challenge of bacterial resistance preparedness, which relies on the development of highly efficient total synthesis strategies. The solid-phase strategy has become important to circumvent tedious intermediate isolation and purification procedures with simple filtrations. This review will give a brief overview of recent applications of solid-phase strategy in the total synthesis of antibiotics. |
format | Online Article Text |
id | pubmed-9043915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90439152022-04-28 Recent applications of solid-phase strategy in total synthesis of antibiotics Zhou, Yuxin Liang, Xiao-Wei RSC Adv Chemistry Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established to search for existing antibiotics-based next-generation drug candidates that can conquer the challenge of bacterial resistance preparedness, which relies on the development of highly efficient total synthesis strategies. The solid-phase strategy has become important to circumvent tedious intermediate isolation and purification procedures with simple filtrations. This review will give a brief overview of recent applications of solid-phase strategy in the total synthesis of antibiotics. The Royal Society of Chemistry 2021-11-24 /pmc/articles/PMC9043915/ /pubmed/35498098 http://dx.doi.org/10.1039/d1ra07503a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Zhou, Yuxin Liang, Xiao-Wei Recent applications of solid-phase strategy in total synthesis of antibiotics |
title | Recent applications of solid-phase strategy in total synthesis of antibiotics |
title_full | Recent applications of solid-phase strategy in total synthesis of antibiotics |
title_fullStr | Recent applications of solid-phase strategy in total synthesis of antibiotics |
title_full_unstemmed | Recent applications of solid-phase strategy in total synthesis of antibiotics |
title_short | Recent applications of solid-phase strategy in total synthesis of antibiotics |
title_sort | recent applications of solid-phase strategy in total synthesis of antibiotics |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043915/ https://www.ncbi.nlm.nih.gov/pubmed/35498098 http://dx.doi.org/10.1039/d1ra07503a |
work_keys_str_mv | AT zhouyuxin recentapplicationsofsolidphasestrategyintotalsynthesisofantibiotics AT liangxiaowei recentapplicationsofsolidphasestrategyintotalsynthesisofantibiotics |