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Recent applications of solid-phase strategy in total synthesis of antibiotics

Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established...

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Detalles Bibliográficos
Autores principales: Zhou, Yuxin, Liang, Xiao-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043915/
https://www.ncbi.nlm.nih.gov/pubmed/35498098
http://dx.doi.org/10.1039/d1ra07503a
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author Zhou, Yuxin
Liang, Xiao-Wei
author_facet Zhou, Yuxin
Liang, Xiao-Wei
author_sort Zhou, Yuxin
collection PubMed
description Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established to search for existing antibiotics-based next-generation drug candidates that can conquer the challenge of bacterial resistance preparedness, which relies on the development of highly efficient total synthesis strategies. The solid-phase strategy has become important to circumvent tedious intermediate isolation and purification procedures with simple filtrations. This review will give a brief overview of recent applications of solid-phase strategy in the total synthesis of antibiotics.
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spelling pubmed-90439152022-04-28 Recent applications of solid-phase strategy in total synthesis of antibiotics Zhou, Yuxin Liang, Xiao-Wei RSC Adv Chemistry Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established to search for existing antibiotics-based next-generation drug candidates that can conquer the challenge of bacterial resistance preparedness, which relies on the development of highly efficient total synthesis strategies. The solid-phase strategy has become important to circumvent tedious intermediate isolation and purification procedures with simple filtrations. This review will give a brief overview of recent applications of solid-phase strategy in the total synthesis of antibiotics. The Royal Society of Chemistry 2021-11-24 /pmc/articles/PMC9043915/ /pubmed/35498098 http://dx.doi.org/10.1039/d1ra07503a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhou, Yuxin
Liang, Xiao-Wei
Recent applications of solid-phase strategy in total synthesis of antibiotics
title Recent applications of solid-phase strategy in total synthesis of antibiotics
title_full Recent applications of solid-phase strategy in total synthesis of antibiotics
title_fullStr Recent applications of solid-phase strategy in total synthesis of antibiotics
title_full_unstemmed Recent applications of solid-phase strategy in total synthesis of antibiotics
title_short Recent applications of solid-phase strategy in total synthesis of antibiotics
title_sort recent applications of solid-phase strategy in total synthesis of antibiotics
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043915/
https://www.ncbi.nlm.nih.gov/pubmed/35498098
http://dx.doi.org/10.1039/d1ra07503a
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