Genome-wide CRISPR/Cas9 screening identifies determinant of panobinostat sensitivity in acute lymphoblastic leukemia

Epigenetic alterations, including histone acetylation, contribute to the malignant transformation of hematopoietic cells and disease progression, as well as the emergence of chemotherapy resistance. Targeting histone acetylation provides new strategies for the treatment of cancers. As a pan-histone...

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Detalles Bibliográficos
Autores principales: Jiang, Chuang, Qian, Maoxiang, Gocho, Yoshihiro, Yang, Wentao, Du, Guoqing, Shen, Shuhong, Yang, Jun J., Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043932/
https://www.ncbi.nlm.nih.gov/pubmed/35192680
http://dx.doi.org/10.1182/bloodadvances.2021006152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043932/
https://www.ncbi.nlm.nih.gov/pubmed/35192680
http://dx.doi.org/10.1182/bloodadvances.2021006152

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