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Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction
Visible light-induced acylation of heteroaromatic compounds have been achieved using benzoyl hydrazides as an efficient acyl source under mild reaction conditions. The photo-redox catalyzed oxidative cleavage of hydrazides leads to in situ formation of acyl radicals, which subsequently couple with v...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044185/ https://www.ncbi.nlm.nih.gov/pubmed/35493212 http://dx.doi.org/10.1039/d1ra07063k |
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author | Hafeez, Saira Saeed, Aamer |
author_facet | Hafeez, Saira Saeed, Aamer |
author_sort | Hafeez, Saira |
collection | PubMed |
description | Visible light-induced acylation of heteroaromatic compounds have been achieved using benzoyl hydrazides as an efficient acyl source under mild reaction conditions. The photo-redox catalyzed oxidative cleavage of hydrazides leads to in situ formation of acyl radicals, which subsequently couple with various N-heterocycles to produce acylated products. This synthetic strategy performs the classic Minisci reaction in an eco-friendly and greener way with functional group tolerance and regioselectivity. Control experiments confirm the radical pathway for this transformation. |
format | Online Article Text |
id | pubmed-9044185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90441852022-04-28 Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction Hafeez, Saira Saeed, Aamer RSC Adv Chemistry Visible light-induced acylation of heteroaromatic compounds have been achieved using benzoyl hydrazides as an efficient acyl source under mild reaction conditions. The photo-redox catalyzed oxidative cleavage of hydrazides leads to in situ formation of acyl radicals, which subsequently couple with various N-heterocycles to produce acylated products. This synthetic strategy performs the classic Minisci reaction in an eco-friendly and greener way with functional group tolerance and regioselectivity. Control experiments confirm the radical pathway for this transformation. The Royal Society of Chemistry 2021-12-01 /pmc/articles/PMC9044185/ /pubmed/35493212 http://dx.doi.org/10.1039/d1ra07063k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Hafeez, Saira Saeed, Aamer Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction |
title | Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction |
title_full | Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction |
title_fullStr | Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction |
title_full_unstemmed | Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction |
title_short | Photo-redox catalyzed dehydrazinative acylation of N-heterocycles via Minisci reaction |
title_sort | photo-redox catalyzed dehydrazinative acylation of n-heterocycles via minisci reaction |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044185/ https://www.ncbi.nlm.nih.gov/pubmed/35493212 http://dx.doi.org/10.1039/d1ra07063k |
work_keys_str_mv | AT hafeezsaira photoredoxcatalyzeddehydrazinativeacylationofnheterocyclesviaminiscireaction AT saeedaamer photoredoxcatalyzeddehydrazinativeacylationofnheterocyclesviaminiscireaction |