Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne

An efficient method for stereoselective synthesis of trifluorinated enol esters catalyzed by base was introduced. The DFT calculations and experimental results both supported the nucleophilic addition process. The protocol featured mild reaction conditions and showed a wide functional group toleranc...

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Detalles Bibliográficos
Autores principales: Zeng, Ji-Jun, Zhao, Bo, Tang, Xiao-Bo, Han, Sheng, Yang, Zhi-Qiang, Liu, Ze-Peng, Zhang, Wei, Lu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044190/
https://www.ncbi.nlm.nih.gov/pubmed/35493246
http://dx.doi.org/10.1039/d1ra06526b
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author Zeng, Ji-Jun
Zhao, Bo
Tang, Xiao-Bo
Han, Sheng
Yang, Zhi-Qiang
Liu, Ze-Peng
Zhang, Wei
Lu, Jian
author_facet Zeng, Ji-Jun
Zhao, Bo
Tang, Xiao-Bo
Han, Sheng
Yang, Zhi-Qiang
Liu, Ze-Peng
Zhang, Wei
Lu, Jian
author_sort Zeng, Ji-Jun
collection PubMed
description An efficient method for stereoselective synthesis of trifluorinated enol esters catalyzed by base was introduced. The DFT calculations and experimental results both supported the nucleophilic addition process. The protocol featured mild reaction conditions and showed a wide functional group tolerance. The one-pot simultaneous etherification and esterification of the salicylic acids further demonstrated the prospective synthetic application.
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spelling pubmed-90441902022-04-28 Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne Zeng, Ji-Jun Zhao, Bo Tang, Xiao-Bo Han, Sheng Yang, Zhi-Qiang Liu, Ze-Peng Zhang, Wei Lu, Jian RSC Adv Chemistry An efficient method for stereoselective synthesis of trifluorinated enol esters catalyzed by base was introduced. The DFT calculations and experimental results both supported the nucleophilic addition process. The protocol featured mild reaction conditions and showed a wide functional group tolerance. The one-pot simultaneous etherification and esterification of the salicylic acids further demonstrated the prospective synthetic application. The Royal Society of Chemistry 2021-12-06 /pmc/articles/PMC9044190/ /pubmed/35493246 http://dx.doi.org/10.1039/d1ra06526b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zeng, Ji-Jun
Zhao, Bo
Tang, Xiao-Bo
Han, Sheng
Yang, Zhi-Qiang
Liu, Ze-Peng
Zhang, Wei
Lu, Jian
Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
title Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
title_full Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
title_fullStr Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
title_full_unstemmed Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
title_short Metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
title_sort metal-free catalytic hydrocarboxylation of hexafluorobut-2-yne
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044190/
https://www.ncbi.nlm.nih.gov/pubmed/35493246
http://dx.doi.org/10.1039/d1ra06526b
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