Application of Pauson–Khand reaction in the total synthesis of terpenes

The Pauson–Khand reaction (PKR) is a formal [2 + 2 + 1] cycloaddition involving an alkyne, an alkene and carbon monoxide mediated by a hexacarbonyldicobaltalkyne complex to yield cyclopentenones in a single step. This versatile reaction has become a method of choice for the synthesis of cyclopenteno...

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Detalles Bibliográficos
Autores principales: Heravi, Majid M., Mohammadi, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044263/
https://www.ncbi.nlm.nih.gov/pubmed/35493249
http://dx.doi.org/10.1039/d1ra05673e
Descripción
Sumario:The Pauson–Khand reaction (PKR) is a formal [2 + 2 + 1] cycloaddition involving an alkyne, an alkene and carbon monoxide mediated by a hexacarbonyldicobaltalkyne complex to yield cyclopentenones in a single step. This versatile reaction has become a method of choice for the synthesis of cyclopentenone and its derivatives since its discovery in the early seventies. The aim of this review is to point out the applications of PKR in the total synthesis of terpenes.

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