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Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions
Herein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkyn...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044274/ https://www.ncbi.nlm.nih.gov/pubmed/35493263 http://dx.doi.org/10.1039/d1ra08322h |
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author | Cui, Menghan Su, Changhui Wang, Rong Yang, Qing Kuang, Chunxiang |
author_facet | Cui, Menghan Su, Changhui Wang, Rong Yang, Qing Kuang, Chunxiang |
author_sort | Cui, Menghan |
collection | PubMed |
description | Herein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Moreover, good yields with excellent functional group tolerance are successfully achieved for a range of substrates, including aryl and heteroaryl groups, terminal alkynes and internal alkynes, and various triazole derivatives. This work presents an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach. |
format | Online Article Text |
id | pubmed-9044274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90442742022-04-28 Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions Cui, Menghan Su, Changhui Wang, Rong Yang, Qing Kuang, Chunxiang RSC Adv Chemistry Herein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Moreover, good yields with excellent functional group tolerance are successfully achieved for a range of substrates, including aryl and heteroaryl groups, terminal alkynes and internal alkynes, and various triazole derivatives. This work presents an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach. The Royal Society of Chemistry 2021-12-06 /pmc/articles/PMC9044274/ /pubmed/35493263 http://dx.doi.org/10.1039/d1ra08322h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Cui, Menghan Su, Changhui Wang, Rong Yang, Qing Kuang, Chunxiang Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
title | Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
title_full | Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
title_fullStr | Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
title_full_unstemmed | Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
title_short | Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
title_sort | synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044274/ https://www.ncbi.nlm.nih.gov/pubmed/35493263 http://dx.doi.org/10.1039/d1ra08322h |
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