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Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet

BACKGROUND: Bet1 Golgi vesicular membrane trafficking protein-like (BET1L) rs2280543 single nucleotide polymorphism (SNP) and diet have been independently associated with uterine leiomyoma (UL). However, whether the SNP and diet could jointly influence the risk of UL is yet to be assessed. Therefore...

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Autores principales: Lee, Shan Chih, Chou, Ying-Hsiang, Tantoh, Disline Manli, Hsu, Shu-Yi, Nfor, Oswald Ndi, Tyan, Yeu Sheng, Liaw, Yung-Po
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044639/
https://www.ncbi.nlm.nih.gov/pubmed/35477381
http://dx.doi.org/10.1186/s12905-022-01721-1
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author Lee, Shan Chih
Chou, Ying-Hsiang
Tantoh, Disline Manli
Hsu, Shu-Yi
Nfor, Oswald Ndi
Tyan, Yeu Sheng
Liaw, Yung-Po
author_facet Lee, Shan Chih
Chou, Ying-Hsiang
Tantoh, Disline Manli
Hsu, Shu-Yi
Nfor, Oswald Ndi
Tyan, Yeu Sheng
Liaw, Yung-Po
author_sort Lee, Shan Chih
collection PubMed
description BACKGROUND: Bet1 Golgi vesicular membrane trafficking protein-like (BET1L) rs2280543 single nucleotide polymorphism (SNP) and diet have been independently associated with uterine leiomyoma (UL). However, whether the SNP and diet could jointly influence the risk of UL is yet to be assessed. Therefore, we investigated the independent and interactive effects of vegetarian diet and BET1L rs2280543 on uterine fibroids in Taiwanese women. METHODS: We linked participants’ electronic data in the Taiwan Biobank (TWB) database to their medical records in the National Health Insurance Research Database (NHIRD). The TWB had genotypic, lifestyle, and biochemical data between 2008 and 2015 and the NHIRD had data on disease diagnoses between 1998 and 2015. In this study, we included 1997 premenopausal women with complete data. RESULTS: Compared  to participants with the BET1L rs2280543 CC genotype (wildtype), those with CT/CC genotype had an odds ratio (OR) of 0.69 and a 95% confidence interval (CI) of 0.51–0.93. Vegetarian diet and UL were not significantly associated: OR = 1.09 and 95% CI = 0.77–1.55. However, the test for interaction between rs2280543 and vegetarian diet was significant (p = 0.046). Compared to individuals with the CC genotype, the risk of UL was lower among vegetarians with the CT/TT genotype: OR (95% CI) = 0.15 (0.05–0.47). CONCLUSION: The BET1L rs2280543 CT/TT genotype was associated with a lower risk of UL especially among vegetarians. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12905-022-01721-1.
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spelling pubmed-90446392022-04-28 Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet Lee, Shan Chih Chou, Ying-Hsiang Tantoh, Disline Manli Hsu, Shu-Yi Nfor, Oswald Ndi Tyan, Yeu Sheng Liaw, Yung-Po BMC Womens Health Research BACKGROUND: Bet1 Golgi vesicular membrane trafficking protein-like (BET1L) rs2280543 single nucleotide polymorphism (SNP) and diet have been independently associated with uterine leiomyoma (UL). However, whether the SNP and diet could jointly influence the risk of UL is yet to be assessed. Therefore, we investigated the independent and interactive effects of vegetarian diet and BET1L rs2280543 on uterine fibroids in Taiwanese women. METHODS: We linked participants’ electronic data in the Taiwan Biobank (TWB) database to their medical records in the National Health Insurance Research Database (NHIRD). The TWB had genotypic, lifestyle, and biochemical data between 2008 and 2015 and the NHIRD had data on disease diagnoses between 1998 and 2015. In this study, we included 1997 premenopausal women with complete data. RESULTS: Compared  to participants with the BET1L rs2280543 CC genotype (wildtype), those with CT/CC genotype had an odds ratio (OR) of 0.69 and a 95% confidence interval (CI) of 0.51–0.93. Vegetarian diet and UL were not significantly associated: OR = 1.09 and 95% CI = 0.77–1.55. However, the test for interaction between rs2280543 and vegetarian diet was significant (p = 0.046). Compared to individuals with the CC genotype, the risk of UL was lower among vegetarians with the CT/TT genotype: OR (95% CI) = 0.15 (0.05–0.47). CONCLUSION: The BET1L rs2280543 CT/TT genotype was associated with a lower risk of UL especially among vegetarians. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12905-022-01721-1. BioMed Central 2022-04-27 /pmc/articles/PMC9044639/ /pubmed/35477381 http://dx.doi.org/10.1186/s12905-022-01721-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lee, Shan Chih
Chou, Ying-Hsiang
Tantoh, Disline Manli
Hsu, Shu-Yi
Nfor, Oswald Ndi
Tyan, Yeu Sheng
Liaw, Yung-Po
Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
title Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
title_full Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
title_fullStr Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
title_full_unstemmed Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
title_short Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet
title_sort risk of uterine leiomyoma based on bet1l rs2280543 single nucleotide polymorphism and vegetarian diet
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044639/
https://www.ncbi.nlm.nih.gov/pubmed/35477381
http://dx.doi.org/10.1186/s12905-022-01721-1
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