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Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study

BACKGROUND: Calcific aortic valve stenosis (CAVS) represents a serious health threat to elderly patients. Post-stenotic aortic dilation, a common feature in CAVS patients, might progress into aneurysm and even dissection, potential consequences of CAVS, and predicts a poor prognosis. This study soug...

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Autores principales: Chen, Shanghao, Wu, Zezhong, Yun, Yan, Shen, Hechen, Zhao, Diming, Liu, Yanwu, Zou, Chengwei, Zhang, Haizhou, Wang, Zhengjun, Ma, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044758/
https://www.ncbi.nlm.nih.gov/pubmed/35473483
http://dx.doi.org/10.1186/s12872-022-02636-3
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author Chen, Shanghao
Wu, Zezhong
Yun, Yan
Shen, Hechen
Zhao, Diming
Liu, Yanwu
Zou, Chengwei
Zhang, Haizhou
Wang, Zhengjun
Ma, Xiaochun
author_facet Chen, Shanghao
Wu, Zezhong
Yun, Yan
Shen, Hechen
Zhao, Diming
Liu, Yanwu
Zou, Chengwei
Zhang, Haizhou
Wang, Zhengjun
Ma, Xiaochun
author_sort Chen, Shanghao
collection PubMed
description BACKGROUND: Calcific aortic valve stenosis (CAVS) represents a serious health threat to elderly patients. Post-stenotic aortic dilation, a common feature in CAVS patients, might progress into aneurysm and even dissection, potential consequences of CAVS, and predicts a poor prognosis. This study sought to investigate the association of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, with severe post-stenotic aortic dilation in a case–control study in Chinese population. MATERIALS AND METHODS: 208 consecutive patients with CAVS were recruited retrospectively in a case–control study in Chinese population, from July 1, 2015 to June 31, 2018. LMR was statistically analyzed using the ROC curve and binary logistic regression analyses for its prognostic value in severe post-stenotic aortic dilation. RESULTS: LMR was significantly reduced in patients with severe post-stenotic aortic dilation (2.72 vs. 3.53, p = 0.002 < 0.05) compared to patients without severe post-stenotic aortic dilation. There was an inverse correlation observed between the maximal diameter of ascending aorta and LMR in the overall patients (r = − 0.217, p = 0.002 < 0.05). For post-stenotic aortic dilation, the prevalence of high-LMR group was statistically lower than that of low-LMR group (19.7% vs. 43.9%, p < 0.001). The maximal diameter of ascending aorta was significantly reduced in the high-LMR group (4.35 vs. 4.76, p = 0.003 < 0.05) compared to low-LMR group. Additionally, LMR was identified in the multivariate analysis independently associated with severe post-stenotic aortic dilation (AUC 0.743, 95% CI: [0.573–0.964], p = 0.025). CONCLUSIONS: This study provided the evidence of an inverse correlation between severe post-stenotic aortic dilation and LMR. LMR is potentially independently associated with severe post-stenotic aortic dilation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-022-02636-3.
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spelling pubmed-90447582022-04-28 Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study Chen, Shanghao Wu, Zezhong Yun, Yan Shen, Hechen Zhao, Diming Liu, Yanwu Zou, Chengwei Zhang, Haizhou Wang, Zhengjun Ma, Xiaochun BMC Cardiovasc Disord Research BACKGROUND: Calcific aortic valve stenosis (CAVS) represents a serious health threat to elderly patients. Post-stenotic aortic dilation, a common feature in CAVS patients, might progress into aneurysm and even dissection, potential consequences of CAVS, and predicts a poor prognosis. This study sought to investigate the association of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, with severe post-stenotic aortic dilation in a case–control study in Chinese population. MATERIALS AND METHODS: 208 consecutive patients with CAVS were recruited retrospectively in a case–control study in Chinese population, from July 1, 2015 to June 31, 2018. LMR was statistically analyzed using the ROC curve and binary logistic regression analyses for its prognostic value in severe post-stenotic aortic dilation. RESULTS: LMR was significantly reduced in patients with severe post-stenotic aortic dilation (2.72 vs. 3.53, p = 0.002 < 0.05) compared to patients without severe post-stenotic aortic dilation. There was an inverse correlation observed between the maximal diameter of ascending aorta and LMR in the overall patients (r = − 0.217, p = 0.002 < 0.05). For post-stenotic aortic dilation, the prevalence of high-LMR group was statistically lower than that of low-LMR group (19.7% vs. 43.9%, p < 0.001). The maximal diameter of ascending aorta was significantly reduced in the high-LMR group (4.35 vs. 4.76, p = 0.003 < 0.05) compared to low-LMR group. Additionally, LMR was identified in the multivariate analysis independently associated with severe post-stenotic aortic dilation (AUC 0.743, 95% CI: [0.573–0.964], p = 0.025). CONCLUSIONS: This study provided the evidence of an inverse correlation between severe post-stenotic aortic dilation and LMR. LMR is potentially independently associated with severe post-stenotic aortic dilation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-022-02636-3. BioMed Central 2022-04-26 /pmc/articles/PMC9044758/ /pubmed/35473483 http://dx.doi.org/10.1186/s12872-022-02636-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Shanghao
Wu, Zezhong
Yun, Yan
Shen, Hechen
Zhao, Diming
Liu, Yanwu
Zou, Chengwei
Zhang, Haizhou
Wang, Zhengjun
Ma, Xiaochun
Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
title Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
title_full Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
title_fullStr Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
title_full_unstemmed Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
title_short Lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
title_sort lymphocyte-to-monocyte ratio associated with severe post-stenotic aortic dilation in a case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044758/
https://www.ncbi.nlm.nih.gov/pubmed/35473483
http://dx.doi.org/10.1186/s12872-022-02636-3
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