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Decellularization of tumours: A new frontier in tissue engineering
Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts int...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044784/ https://www.ncbi.nlm.nih.gov/pubmed/35495097 http://dx.doi.org/10.1177/20417314221091682 |
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author | García-Gareta, Elena Pérez, María Ángeles García-Aznar, José Manuel |
author_facet | García-Gareta, Elena Pérez, María Ángeles García-Aznar, José Manuel |
author_sort | García-Gareta, Elena |
collection | PubMed |
description | Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes. |
format | Online Article Text |
id | pubmed-9044784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90447842022-04-28 Decellularization of tumours: A new frontier in tissue engineering García-Gareta, Elena Pérez, María Ángeles García-Aznar, José Manuel J Tissue Eng Review Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes. SAGE Publications 2022-04-25 /pmc/articles/PMC9044784/ /pubmed/35495097 http://dx.doi.org/10.1177/20417314221091682 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review García-Gareta, Elena Pérez, María Ángeles García-Aznar, José Manuel Decellularization of tumours: A new frontier in tissue engineering |
title | Decellularization of tumours: A new frontier in tissue
engineering |
title_full | Decellularization of tumours: A new frontier in tissue
engineering |
title_fullStr | Decellularization of tumours: A new frontier in tissue
engineering |
title_full_unstemmed | Decellularization of tumours: A new frontier in tissue
engineering |
title_short | Decellularization of tumours: A new frontier in tissue
engineering |
title_sort | decellularization of tumours: a new frontier in tissue
engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044784/ https://www.ncbi.nlm.nih.gov/pubmed/35495097 http://dx.doi.org/10.1177/20417314221091682 |
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