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Decellularization of tumours: A new frontier in tissue engineering

Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts int...

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Autores principales: García-Gareta, Elena, Pérez, María Ángeles, García-Aznar, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044784/
https://www.ncbi.nlm.nih.gov/pubmed/35495097
http://dx.doi.org/10.1177/20417314221091682
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author García-Gareta, Elena
Pérez, María Ángeles
García-Aznar, José Manuel
author_facet García-Gareta, Elena
Pérez, María Ángeles
García-Aznar, José Manuel
author_sort García-Gareta, Elena
collection PubMed
description Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes.
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spelling pubmed-90447842022-04-28 Decellularization of tumours: A new frontier in tissue engineering García-Gareta, Elena Pérez, María Ángeles García-Aznar, José Manuel J Tissue Eng Review Cancer is one of the leading causes of death worldwide. The tumour extracellular matrix (ECM) has unique features in terms of composition and mechanical properties, resulting in a structurally and chemically different ECM to that of native, healthy tissues. This paper reviews to date the efforts into decellularization of tumours, which in the authors’ view represents a new frontier in the ever evolving field of tumour tissue engineering. An overview of the ECM and its importance in cancer is given, ending with examples of research using decellularized tumours, which has already indicated potential therapeutic targets, unravelled malignancy mechanisms or response to chemotherapy agents. The review highlights that more research is needed in this area, which can answer important questions related to tumour formation and progression to ultimately identify new and effective therapeutic targets. Within the near-future of personalized medicine, this research can create patient-specific tumour models and therapeutic regimes. SAGE Publications 2022-04-25 /pmc/articles/PMC9044784/ /pubmed/35495097 http://dx.doi.org/10.1177/20417314221091682 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
García-Gareta, Elena
Pérez, María Ángeles
García-Aznar, José Manuel
Decellularization of tumours: A new frontier in tissue engineering
title Decellularization of tumours: A new frontier in tissue engineering
title_full Decellularization of tumours: A new frontier in tissue engineering
title_fullStr Decellularization of tumours: A new frontier in tissue engineering
title_full_unstemmed Decellularization of tumours: A new frontier in tissue engineering
title_short Decellularization of tumours: A new frontier in tissue engineering
title_sort decellularization of tumours: a new frontier in tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044784/
https://www.ncbi.nlm.nih.gov/pubmed/35495097
http://dx.doi.org/10.1177/20417314221091682
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