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Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress

BACKGROUND: The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critically cont...

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Autores principales: Choi, Hong Sang, Mathew, Ansuja Pulickal, Uthaman, Saji, Vasukutty, Arathy, Kim, In Jin, Suh, Sang Heon, Kim, Chang Seong, Ma, Seong Kwon, Graham, Sontyana Adonijah, Kim, Soo Wan, Park, In-Kyu, Bae, Eun Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044883/
https://www.ncbi.nlm.nih.gov/pubmed/35477452
http://dx.doi.org/10.1186/s12951-022-01410-z
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author Choi, Hong Sang
Mathew, Ansuja Pulickal
Uthaman, Saji
Vasukutty, Arathy
Kim, In Jin
Suh, Sang Heon
Kim, Chang Seong
Ma, Seong Kwon
Graham, Sontyana Adonijah
Kim, Soo Wan
Park, In-Kyu
Bae, Eun Hui
author_facet Choi, Hong Sang
Mathew, Ansuja Pulickal
Uthaman, Saji
Vasukutty, Arathy
Kim, In Jin
Suh, Sang Heon
Kim, Chang Seong
Ma, Seong Kwon
Graham, Sontyana Adonijah
Kim, Soo Wan
Park, In-Kyu
Bae, Eun Hui
author_sort Choi, Hong Sang
collection PubMed
description BACKGROUND: The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critically contributes to the progression of chronic kidney disease and finally, end-stage renal disease. Thus, delivering therapeutic agents to the ROS-rich inflammation site and releasing the therapeutic agents is a feasible solution. RESULTS: We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn(3)O(4) (dMn(3)O(4)) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Hydrophobic dMn(3)O(4) nanoparticles were loaded inside PTC micelles to prevent premature release during circulation and act as a therapeutic agent by ROS-responsive release of loaded dMn(3)O(4) once it reached the inflammation site. CONCLUSIONS: The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01410-z.
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spelling pubmed-90448832022-04-28 Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress Choi, Hong Sang Mathew, Ansuja Pulickal Uthaman, Saji Vasukutty, Arathy Kim, In Jin Suh, Sang Heon Kim, Chang Seong Ma, Seong Kwon Graham, Sontyana Adonijah Kim, Soo Wan Park, In-Kyu Bae, Eun Hui J Nanobiotechnology Research BACKGROUND: The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thus, the vicious cycle between oxidative stress and renal hypoxia critically contributes to the progression of chronic kidney disease and finally, end-stage renal disease. Thus, delivering therapeutic agents to the ROS-rich inflammation site and releasing the therapeutic agents is a feasible solution. RESULTS: We developed a longer-circulating, inflammation-sensing, ROS-scavenging versatile nanoplatform by stably loading catalase-mimicking 1-dodecanethiol stabilized Mn(3)O(4) (dMn(3)O(4)) nanoparticles inside ROS-sensitive nanomicelles (PTC), resulting in an ROS-sensitive nanozyme (PTC-M). Hydrophobic dMn(3)O(4) nanoparticles were loaded inside PTC micelles to prevent premature release during circulation and act as a therapeutic agent by ROS-responsive release of loaded dMn(3)O(4) once it reached the inflammation site. CONCLUSIONS: The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01410-z. BioMed Central 2022-04-27 /pmc/articles/PMC9044883/ /pubmed/35477452 http://dx.doi.org/10.1186/s12951-022-01410-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Choi, Hong Sang
Mathew, Ansuja Pulickal
Uthaman, Saji
Vasukutty, Arathy
Kim, In Jin
Suh, Sang Heon
Kim, Chang Seong
Ma, Seong Kwon
Graham, Sontyana Adonijah
Kim, Soo Wan
Park, In-Kyu
Bae, Eun Hui
Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
title Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
title_full Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
title_fullStr Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
title_full_unstemmed Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
title_short Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
title_sort inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044883/
https://www.ncbi.nlm.nih.gov/pubmed/35477452
http://dx.doi.org/10.1186/s12951-022-01410-z
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