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Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332

The high mutation rate of COVID-19 and the prevalence of multiple variants strongly support the need for pharmacological options to complement vaccine strategies. One region that appears highly conserved among different genera of coronaviruses is the substrate-binding site of the main protease (M(pr...

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Detalles Bibliográficos
Autores principales:	Li, Jian, Lin, Cheng, Zhou, Xuelan, Zhong, Fanglin, Zeng, Pei, Yang, Yang, Zhang, Yuting, Yu, Bo, Fan, Xiaona, McCormick, Peter J., Fu, Rui, Fu, Yang, Jiang, Haihai, Zhang, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044943/ https://www.ncbi.nlm.nih.gov/pubmed/35389231 http://dx.doi.org/10.1128/jvi.02013-21

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