Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directs infection of the lungs and other tissues following its binding to the angiotensin-converting enzyme 2 (ACE2) receptor. For effective infection, the S protein is cleaved at two sites: S1/S2 and S2′. The “pri...

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Detalles Bibliográficos
Autores principales: Essalmani, Rachid, Jain, Jaspreet, Susan-Resiga, Delia, Andréo, Ursula, Evagelidis, Alexandra, Derbali, Rabeb Mouna, Huynh, David N., Dallaire, Frédéric, Laporte, Mélanie, Delpal, Adrien, Sutto-Ortiz, Priscila, Coutard, Bruno, Mapa, Claudine, Wilcoxen, Keith, Decroly, Etienne, NQ Pham, Tram, Cohen, Éric A., Seidah, Nabil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044946/
https://www.ncbi.nlm.nih.gov/pubmed/35343766
http://dx.doi.org/10.1128/jvi.00128-22

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