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Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy

BACKGROUND: Left atrial (LA) function and mechanical dispersion changes in breast cancer patients treated with chemotherapy remain unclear. HYPOTHESIS: LA function and LA mechanical dispersion in breast cancer patients would be impaired after chemotherapy. METHODS: This single‐center retrospective s...

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Autores principales: Chen, Na, Liu, Ansheng, Sun, Siyao, Wei, Hong, Sun, Qiaobing, Shang, Zhijuan, Sun, Yinghui, Fu, Tingting, Wang, Hongjiang, Xia, Yunlong, Hua, Lanqi, Hsi, David H., Cong, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045082/
https://www.ncbi.nlm.nih.gov/pubmed/35294063
http://dx.doi.org/10.1002/clc.23813
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author Chen, Na
Liu, Ansheng
Sun, Siyao
Wei, Hong
Sun, Qiaobing
Shang, Zhijuan
Sun, Yinghui
Fu, Tingting
Wang, Hongjiang
Xia, Yunlong
Hua, Lanqi
Hsi, David H.
Cong, Tao
author_facet Chen, Na
Liu, Ansheng
Sun, Siyao
Wei, Hong
Sun, Qiaobing
Shang, Zhijuan
Sun, Yinghui
Fu, Tingting
Wang, Hongjiang
Xia, Yunlong
Hua, Lanqi
Hsi, David H.
Cong, Tao
author_sort Chen, Na
collection PubMed
description BACKGROUND: Left atrial (LA) function and mechanical dispersion changes in breast cancer patients treated with chemotherapy remain unclear. HYPOTHESIS: LA function and LA mechanical dispersion in breast cancer patients would be impaired after chemotherapy. METHODS: This single‐center retrospective study included 91 consecutive breast cancer patients treated with chemotherapy and 30 controls. Patients were examined by echocardiography three times at intervals. Conventional parameters, left ventricular strain, LA strain, and LA mechanical dispersion were evaluated and compared. RESULTS: LA strain during reservoir phase (LASr), conduit phase (LAScd), and contraction phase (LASct) all decreased markedly after chemotherapy and were lower than those of the controls (all p < .01). The standard deviation of time to peak positive strain during LA reservoir phase corrected by R‐R interval (LA SD‐TPSr) was significantly increased after chemotherapy and was higher than that of the controls (p < .001). The change of LA function was expressed as Δ. Multivariate linear regression analyses showed that LAVIp (0.399, 95% confidence interval [CI]: 0.610, 1.756, p = .000) was independently associated with ΔLASr, LAPEF (−0.325, 95% CI: −45.123, −10.676, p = .002) and age (0.227, 95% CI: 0.021, 0.350, p = .027) were independently associated with ΔLAScd, and LAVImax (0.341, 95% CI: 0.192, 0.723, p = .001) was independently associated with ΔLASct. LAVImax (0.505, 95% CI: 0.000, 0.001, p = .039) and mitral E (−0.256, 95% CI: 0.000, 0.000, p = .024)were independently associated with ΔLA SD‐TPSr. CONCLUSIONS: Mechanical function of LA declined after chemotherapy in breast cancer patients. With the decrease of LA mechanical function, LA mechanical dispersion assessed by two‐dimensional speckle‐tracking echocardiography increased significantly, and its clinical value needs to be further studied.
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spelling pubmed-90450822022-04-28 Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy Chen, Na Liu, Ansheng Sun, Siyao Wei, Hong Sun, Qiaobing Shang, Zhijuan Sun, Yinghui Fu, Tingting Wang, Hongjiang Xia, Yunlong Hua, Lanqi Hsi, David H. Cong, Tao Clin Cardiol Clinical Investigations BACKGROUND: Left atrial (LA) function and mechanical dispersion changes in breast cancer patients treated with chemotherapy remain unclear. HYPOTHESIS: LA function and LA mechanical dispersion in breast cancer patients would be impaired after chemotherapy. METHODS: This single‐center retrospective study included 91 consecutive breast cancer patients treated with chemotherapy and 30 controls. Patients were examined by echocardiography three times at intervals. Conventional parameters, left ventricular strain, LA strain, and LA mechanical dispersion were evaluated and compared. RESULTS: LA strain during reservoir phase (LASr), conduit phase (LAScd), and contraction phase (LASct) all decreased markedly after chemotherapy and were lower than those of the controls (all p < .01). The standard deviation of time to peak positive strain during LA reservoir phase corrected by R‐R interval (LA SD‐TPSr) was significantly increased after chemotherapy and was higher than that of the controls (p < .001). The change of LA function was expressed as Δ. Multivariate linear regression analyses showed that LAVIp (0.399, 95% confidence interval [CI]: 0.610, 1.756, p = .000) was independently associated with ΔLASr, LAPEF (−0.325, 95% CI: −45.123, −10.676, p = .002) and age (0.227, 95% CI: 0.021, 0.350, p = .027) were independently associated with ΔLAScd, and LAVImax (0.341, 95% CI: 0.192, 0.723, p = .001) was independently associated with ΔLASct. LAVImax (0.505, 95% CI: 0.000, 0.001, p = .039) and mitral E (−0.256, 95% CI: 0.000, 0.000, p = .024)were independently associated with ΔLA SD‐TPSr. CONCLUSIONS: Mechanical function of LA declined after chemotherapy in breast cancer patients. With the decrease of LA mechanical function, LA mechanical dispersion assessed by two‐dimensional speckle‐tracking echocardiography increased significantly, and its clinical value needs to be further studied. John Wiley and Sons Inc. 2022-03-16 /pmc/articles/PMC9045082/ /pubmed/35294063 http://dx.doi.org/10.1002/clc.23813 Text en © 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigations
Chen, Na
Liu, Ansheng
Sun, Siyao
Wei, Hong
Sun, Qiaobing
Shang, Zhijuan
Sun, Yinghui
Fu, Tingting
Wang, Hongjiang
Xia, Yunlong
Hua, Lanqi
Hsi, David H.
Cong, Tao
Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
title Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
title_full Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
title_fullStr Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
title_full_unstemmed Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
title_short Evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
title_sort evaluation of left atrial function and mechanical dispersion in breast cancer patients after chemotherapy
topic Clinical Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045082/
https://www.ncbi.nlm.nih.gov/pubmed/35294063
http://dx.doi.org/10.1002/clc.23813
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