Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients

De novo mutations in the UL56 terminase subunit and its associated phenotypes were studied in the context of cytomegalovirus (CMV) transplant recipients clinically resistant to DNA-polymerase inhibitors, naive to letermovir. R246C was the only UL56 variant detected by standard and deep sequencing, l...

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Detalles Bibliográficos
Autores principales: Santos Bravo, Marta, Tilloy, Valentin, Plault, Nicolas, Palomino, Sonsoles Sánchez, Mosquera, María Mar, Navarro Gabriel, Mireia, Fernández Avilés, Francesc, Suárez Lledó, María, Rovira, Montserrat, Moreno, Asunción, Linares, Laura, Bodro, Marta, Hantz, Sébastien, Alain, Sophie, Marcos, María Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045154/
https://www.ncbi.nlm.nih.gov/pubmed/35343771
http://dx.doi.org/10.1128/spectrum.00191-22

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